Table 2 Information about the articles included in this study NR: Not reported, SI: selectivity index, MRC5: human embryonic lung fibroblast

[37]

MERS-COV-2/MRC-5

Silvestrol/ Meliaceae

SI, Virus titer

24 h

 > 7690

0.0013 µM/L

HCoV-229E/ MRC-5

 > 3330

0.003 µM/L

HCoV-229E/ PBMCs

 > 350

0.0028 µM/L

HCoV-229E/ Huh-7

 > 0.75

0.040 µM/L

[9]

HCoV-229E/ MRC-5

Saikosaponins B2/ Bupleurum

SI, EC50, Virus inhibition

96 h

221.9

1.7 ± 0.1 µM/L

Saikosaponin A/ Bupleurum

26.6

8.6 ± 0.3 µM/L

Saikosaponin C/ Bupleurum

19.2

19.9 ± 0.1 µM/L

Saikosaponin D/ Bupleurum

13.3

13.2 ± 0.3 µM/L

[7]

SARS-COV strain FFM 1/ African green monkey kidney cell lines Vero

Extract/Yin-Chiau-San

SI, EC50

72 h

 > 1

 > 500(µg/ml)

Extract/ Pu-Zhi-Siau-Du-Yien

 > 2

240(µg/ml)

Extract/ Ger-Gern-Hwang-Lein

 > 3

134(µg/ml)

Extract/ Sang-Zhiu-Yien

 > 1

349(µg/ml)

Extract/ Huang-Lein-Zhei-Du-Tang

 > 1

369(µg/ml)

Extract/ Toona sinensis leaves

17

30(µg/ml)

Extract/ Toona sinensis leaves

 > 13

37 (µg/ml)

Extract /Amaryllidaceae

370

2.4 (± 0.2) (µg/ml)

[25]

SARS-COV (BJ-001)/ Vero E6 cells

Artemisia annua

SI, EC50, Virus inhibition,

72 h

31

34.5(± 2.6) (µg/ml)

Pyrrosia lingua

55

43.2(± 14.1) (µg/ml)

Lindera aggregate

16

88.2(± 7.7) (µg/ml)

SARS-COV (BJ-002)/ Vero E6 cells

Extract/ Lycoris radiata /Amaryllidaceae

422

2.1 (± 0.2) (µg/ml)

Artemisia annua

27

39.2 (± 4.1) (µg/ml)

Pyrrosia lingua

59

40.5 (± 3.7) (µg/ml)

Lindera aggregate

17

80.6 (± 5.2) (µg/ml)

[53]

HCoV-NL63/ LLC-MK2 cells, Calu-3 cells

Caffeic acid /Adoxaceae

Chlorogenic acid/Adoxaceae

Gallic acid/Adoxaceae

Virus inhibition, Virus titer

NR

NR

[20]

SARS-COV / Vero E6 cells

Lectin (Man-specific agglutinins)(APA/ Alliaceae

SI, EC50

72

 > 222.2

0.45 ± 0.08(µg/ml)

Mannose-specific agglutinins( HHA)

 > 31.3

3.2 ± 2.8(µg/ml)

Mannose-specific agglutinins( GNA)

 > 16.1

6.2 ± 0.6(µg/ml)

Mannose-specific agglutinins( NPA)

 > 17.5

5.7 ± 4.4(µg/ml)

Mannose-specific agglutinins( LRA)

 > 2.1

48(µg/ml)

Mannose-specific agglutinins(AUA)

 > 5.5

18 ± 4(µg/ml)

Mannose-specific agglutinins( CA)

 > 20

4.9 ± 0.8(µg/ml)

Mannose-specific agglutinins( LOA)

 > 45.5

2.2 ± 1.3(µg/ml)

Mannose-specific agglutinins( EHA)

 > 55.5

1.8 ± 0.3(µg/ml)

Mannose-specific agglutinins( TLMI)

 > 2.3

22 ± 6(µg/ml)

Mannose-specific agglutinins( Morniga M II)

 > 62.5

1.6 ± 0.5(µg/ml)

GlcNAc-specific agglutinins Nictaba

 > 58.8

1.7 ± 0.3(µg/ml)

(GlcNAc)n-specific agglutinins UDA

 > 76.9

1.3 ± 0.1(µg/ml)

Gal-specific agglutinins Morniga G II

 > 2

50 ± 13(µg/ml)

Man/Glc-specific agglutinins Cladistris

 > 13.5

7.4 ± 0.2(µg/ml)

Gal/GalNAc specific agglutinins -PMRIP m

 > 5.5

18 ± 13(µg/ml)

GalNAc (> Gal) specific agglutinins/ ML III

 > 12.6

28 ± 11(µg/ml)

GalNAcα(1,3)Gal > GalNAc > Gal-specific agglutinins/IRA

22.7

2.2 ± 0.9(µg/ml)

GalNAcα(1,3)Gal > GalNAc > Gal-specific agglutinins/IRA

8.2

4.4 ± 3.1(µg/ml)

GalNAcα(1,3)Gal > GalNAc > Gal-specific agglutinins/IRA

16.2

3.4 ± 2.0(µg/ml)

Man/GalNAc-specific agglutinins/ TL C II

 > 1.3

38 ± 0(µg/ml)

[22]

SARS-COV, Toronto-2 v2147/ Vero 76

Lectin (N-acetylglucosamine)/ Urticaceae

SI, Virus titer

72 h

54.2 ± 52.5

NR

SARS-COV, Urbani/ Vero 76

10.2 ± 5.6

NR

SARS-COV, Mouse-adapted virus/ Vero 76

42.8 ± 47.5

NR

SARS-COV, Frankfurt v1940/ Vero 76

5.5 ± 2.0

NR

SARS-COV, Hong Kong v2157/ Vero 76

8.6 ± 1.1

NR

[23]

Vero-adapted Beaudette IBV/ Vero

Ethanol extract/ Lamiaceae

SI, EC50, Virus titer

72 h

67.5

0.004 (µg/ml)

Vero-adapted Beaudette IBV/ Satureja montana

17

0.044(µg/ml)

Vero-adapted Beaudette IBV/Origanum vulgare

65

0.008(µg/ml)

Vero-adapted Beaudette IBV/Mentha piperita

67.5

0.015(µg/ml)

Vero-adapted Beaudette IBV/Melissa officinalis

39.3

0.010(µg/ml)

Vero-adapted Beaudette IBV/Hyssopus officinalis,

8.4

0.076(µg/ml)

Vero-adapted Beaudette IBV/ Salvia officinalis,

36.7

0.003(µg/ml)

17.1

0.017(µg/ml)

Vero-adapted Beaudette IBV/Desmodium canadense

[26]

SARS-COV pseudovirus/ HEK293T-ACE2

Sanguisorba/ Rosaceae

Virus inhibition,

NR

NR

[35]

HCo-229E/ Epithelial colorectal adenocarcinoma cells(Caco-2)

Extract/ Pelargonium sidoides/ Geraniaceae

SI, EC50, Virus titer

72 h

 > 2.3

NR

[51]

SARS-COV / Vero E6

Ferruginol

SI, EC50,

72 h

58

1.39 (µM)

Dehydroabieta-7-one

76.3

4

Sugiol

NR

n.t

Cryptojaponol

 < 7.9

 > 10

8â-hydroxyabieta-9(11),13-dien-12-one

 > 510

1.47

7â-hydroxydeoxycryptojaponol

111

1.15

6,7-dehydroroyleanone

16.2

5.55

3â,12-diacetoxyabieta-6,8,11,13-tetraene

193

1.57

Pinusolidic acid

159

4.71

Forskolin

89.8

7.5

Cedrane-3â,12-diol

NR

 > 0

α -cadinol

17.3

4.44

Betulinicacid

 < 15

 > 10

Betulonic acid

180

0.63

Hinokinin

NR

 > 10

Savinin

 > 667

1.13

4,4 ′ -O-benzoylisolaricires-inol

N.C

n.t

Honokiol

13.7

6.50

Magnolol

18

3.80

Curcumin

NR

 > 10

[52]

SARS-COV / Vero E6

Supernatant of Cibotium barometz

SI, EC50

72 h

 > 59.4

8.42 (μg/ml)

70% ethanol precipitated fraction of Cibotium barometz

NR

 > 10(μg/ml)

Dried rhizome of Gentiana scabra

 > 57.5

8.70(μg/ml)

The tuber of Dioscorea batatas

 > 62.0

8.06(μg/ml)

The dried seed of Cassia tora

 > 59.3

8.43(μg/ml)

The dried stem, with leaf of Taxillus chinensis

 > 92.8

5.39(μg/ml)

[55]

PEDV/ Vero cells

Oleanane triterpenes2 / Theaceae

SI, EC50

72 h

13.39 ± 0.67

1.94 ± 0.39 (µM/L)

Oleanane triterpenes3 / Theaceae

5.75 ± 0.75

1.09 ± 0.22 (µM/L)

Oleanane triterpenes6 / Theaceae

44.54 ± 8.34

0.28 ± 0.09 (µM/L)

Oleanane triterpenes7 / Theaceae

7.99 ± 0.28

0.91 ± 0.07 (µM/L)

Oleanane triterpenes8 / Theaceae

12.98 ± 2.34

0.06 ± 0.02 (µM/L)

Oleanane triterpenes9 / Theaceae

32.72 ± 6.22

0.28 ± 0.11 (µM/L)

Oleanane triterpenes10 / Theaceae

9.4 ± 1.04

2.90 ± 0.25 (µM/L)

Oleanane triterpenes11 / Theaceae

14.75 ± 1.62

0.93 ± 0.22 (µM/L)

Oleanane triterpenes13 / Theaceae

6.68 ± 0.14

0.34 ± 0.01 (µM/L)

Oleanane triterpenes15 / Theaceae

6.42 ± 0.58

3.70 ± 0.68 (µM/L)

[56]

Porcine epidemic diarrhea virus (PEDV)/ Vero cells

Coumarins/ Saposhnikovia divaricate1/ Umbelliferae

SI, EC50

72 h

 > 6.25 ± 0.85

16.25 ± 1.97 (µM/L)

Coumarins/ Saposhnikovia divaricate2/ Umbelliferae

 > 5.85 ± 0.80

17.36 ± 2.12 (µM/L)

Coumarins/ Saposhnikovia divaricate3/ Umbelliferae

 > 5.11 ± 0.47

19.70 ± 1.66 (µM/L)

Coumarins/ Saposhnikovia divaricate4/ Umbelliferae

4.07 ± 0.25

3.84 ± 0.45 (µM/L)

Coumarins/ Saposhnikovia divaricate5/ Umbelliferae

 > 23.90 ± 4.11

4.28 ± 0.64 (µM/L)

Coumarins/ Saposhnikovia divaricate6/ Umbelliferae

7.67 ± 0.04

1.09 ± 0.06 (µM/L)

Coumarins/ Saposhnikovia divaricate7/ Umbelliferae

8.21 ± 0.40

1.22 ± 0.09 (µM/L)

Coumarins/ Saposhnikovia divaricate8/ Umbelliferae

7.89 ± 0.97

0.60 ± 0.03 (µM/L)

Coumarins/ Saposhnikovia divaricate9/ Umbelliferae

 > 5.58 ± 0.41

18.00 ± 1.25 (µM/L)

[57]

IBV/ Vero cells

Houttuynia cordata (Saururaceae)

Virus inhibition

1 h

NR

NR

Glycyrrhizinate diammonium (GD)

IBV/ chicken embryo kidney (CEK) cells

Houttuynia cordata (Saururaceae)

Glycyrrhizinate diammonium (GD)

[8]

(IBV) a chicken coronavirus/ Vero cells

Rhodiola rosea, Nigella sativa, Sambucus nigra

Virus titer

3d

NR

NR

[36]

MERS-COV-2 strain EMC/2012/ MRC-5

Griffithsin (GRFT)/ Wrangeliaceae

Virus titer

45 h

NR

NR

[59]

SARS-COV strain PUMC01 F5 / VeroE6

Forsythiae Fructus

SI

72 h

1.4

NR

Scutellariae Radix

1.0

NR

Astragali Radix

1.7

NR

Bupleuri Radix

 < 1

NR

Glycyrrhizae Radix

 < 1

NR

Cinnamomi Cortex (CCE)

6.6

NR

Ethanol extract of CC (Fr.1)

5.2

NR

Butanol fraction of CC (Fr.2)

5.5

NR

Aqueous fraction of CC (Fr.3)

3.9

NR

Ethylacetate fraction of CC (Fr.4)

3.4

NR

Caryophylli Flos (CFE)

12.9

NR

Ethanol extract of CF (Fr.1)

5.4

NR

Butanol fraction of CF (Fr.2)

20.9

NR

Aqueous fraction of CF (Fr.3)

23.4

NR

Ethylacetate fraction of CF (Fr.4)

7.3

NR

[50]

SARS-COV-2/ Vero E6

Artemisinin(LG0019527)

Virus inhibition

1 h

NR

NR

[48]

HCoV-NL63/ LCC-MK2

Trypthantrin

Virus titer

48 h

NR

NR

Indigodole B

[6]

SARS-COV‑2/ Vero E6 cells

Arteether

SI, EC50,

24 h

6.42

31.86 ± 4.72 µM

Artemether

3.13

73.8 ± 26.91

Artemisicacid

3.3

 > 100

Artemisinin

3.11

64.45 ± 2.58

Artemisone

4.03

49.64 ± 1.85

Dihydroartemisinin

2.38

13.31 ± 1.24

Artesunate

5.1

12.98 ± 5.3

Arteannuin

7

10.28 ± 1.12

lumefantrine

4.4

23.17 ± 3.22

[46]

SARS-COV-2/ HepG2

Andrographolide

Virus inhibition

48 h

2398

NR

SARS-COV-2/ imHC

1310

NR

SARS-COV-2/ HK-2

1003

NR

SARS-COV-2/ Caco-2

1538

NR

SARS-COV-2/ Caco-3

1707

NR

SARS-COV-2/ SH-SY5Y

388

NR

[40]

SARS-COV‑2/ Vero E6

Resveratrol

EC50

2 h

NR

66 µM

Pterostilbene

19 µM

[10]

SARS-COV-2/ Vero E6

Homorringtonine

EC50

48 h

NR

2.55 μM

Emetine

0.46 μM

[31]

SARS-COV-2/ Vero E6

Phillyrin (KD-1)

Virus inhibition

72 h

30.66

NR

HCoV-229E/ Vero E6

16.02

[32]

SARS-COV-2/ Vero E6

Liu Shen capsule

Virus inhibition

72 h

8.18

NR

[38]

SARS-COV/ Vero E6

Griffithsin

SI, EC50

3d

 > 164

0.61 µg/ml

[24]

SARS-COV-2/ Vero E6

Corilagin (RAI-S-37)

SI, EC50

24 h

NR

0.13 μmol/L

[45]

SARS-COV-2/ Huh-7

EGYVIR

Virus inhibition

3d

NR

NR

[11]

SARS-COV/ Vero cells

Glycyrrhizin

SI, EC50

72 h

 > 67

300 µg/ml

[21]

HCoV-C43/ MRC-5 human lung cell

Tetrandrine

SI

4d

40.19

NR

Fangchinoline

11.46

NR

Ceparanthine

13.63

NR

[29]

SARS-COV/ Vero

L. nobilis

SI

48 h

4.2

NR

T. orientalis

3.8

NR

J. oxycredrus ssp. Oxycedrus

3.7

NR

Pyramidalis

1.5

NR

P. palaestina

 > 1

NR

S. officinalis

 > 1

NR

S. thymbra

NR

NR

Acyclovir

NR

NR

Glycyrrhizin

1.2

NR