Replication kinetics and infectivity of SARS-CoV-2 variants of concern in common cell culture models

Table 1 Summery of peak values and time points of SARS-CoV-2 non-VOC and VOC replication kinetics in Vero E6, Caco-2, and Calu-3

	Max RNA level [copy number/mL]	Time point of max RNA level [h p.i.]	Max viral infectious titer [TCID50/mL]	Time point of max viral infectious titer [h p.i.]	Time point of visible CPE [h p.i.]
Vero E6
Non-VOC	2.85E+09	96	9.17E+07	56	56
Alpha	1.70E+09	96	1.33E+07	72	56
Beta	2.98E+09	96	3.43E+06	80	80
Gamma	2.20E+09	96	2.40E+07	56	56
Delta	2.11E+09	96	3.63E+06	72	56
Omicron	2.14E+09	96	6.30E+05	96	72
Caco-2
Non-VOC	4.36E+08	96	2.29E+07	96	–
Alpha	4.33E+08	96	1.08E+06	96	–
Beta	1.85E+08	96	1.52E+05	96	–
Gamma	9.30E+08	96	2.06E+06	96	–
Delta	5.86E++08	96	7.87E+05	72	–
Omicron	8.20E+05	96	3.54E+02	96	–
Calu-3
Non-VOC	2.60E+08	96	1.20E+07	80	80
Alpha	1.24E+09	96	5.57E+06	96	72
Beta	1.07E+08	96	1.12E+06	80	96
Gamma	2.67E+09	96	5.16E+06	96	56
Delta	2.48E+09	96	1.98E+06	80	56
Omicron	1.28E+09	96	4.27E+06	96	80

ISSN: 1743-422X