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Fig. 6 | Virology Journal

Fig. 6

From: A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7 × CCL19 results in enhanced antitumor efficacy

Fig. 6

Therapeutic effects of cocktail therapy in the CT26 model. Balb/c mice were subcutaneously implanted with CT26 tumor cells and intratumorally injected with OVs on days 1, 2, 3, 8, 10, 15, 17, 19 (n = 5 per group). A Schematic depiction of the experiment. B Tumor volume growth curves of the OVs and mock-treated groups, data are shown as mean + SD. C The tumor volumes of mice from the control and OVs treated groups on day 37 from (B). ****P < 0.0001 by 1-way ANOA with Tukey’s post hoc test. D Survival is monitored with Kaplan–Meier analysis. **P < 0.01 (vs. 5voHSV2 group) by log-rank test

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Virology Journal

ISSN: 1743-422X