Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19

Table 5 Summary of ROC curve parameters for predicting ICU admission

Predictor	AUC	P value	95% CI	Cutoff value	Jordan index	Sensitivity (%)	Specificity
Age	0.766	< 0.001	0.689–0.844	> 53.50	0.437	69.8	73.9
Diabetes mellitus	0.626	0.006	0.532–0.720	> 0.50	0.252	30.2	95.0
Lymphocyte	0.780	< 0.001	0.709–0.851	< 840.00	0.456	73.6	72.0
CD3⁺	0.806	< 0.001	0.737–0.874	< 510.50	0.512	71.7	79.5
CD4⁺	0.776	< 0.001	0.705–0.847	< 357.50	0.426	77.4	65.2
CD8⁺	0.796	< 0.001	0.721–0.872	< 173.50	0.505	67.9	82.6
CD19⁺	0.616	0.012	0.533–0.699	< 148.00	0.196	81.1	38.5
NK	0.639	0.002	0.553–0.725	< 134.50	0.270	71.7	55.3
IL-4	0.526	0.573	0.433–0.618	< 1.27	0.096	26.4	83.2
IL-6	0.785	< 0.001	0.705–0.864	> 6.58	0.519	77.4	74.5
IL-10	0.760	< 0.001	0.681–0.838	> 2.95	0.494	77.4	72.0
IL-17	0.539	0.393	0.451–0.627	< 1.27	0.096	69.8	39.8
TNF-α	0.539	0.390	0.452–0.626	< 8.40	0.099	96.2	13.7
IFN-γ	0.548	0.295	0.460–0.636	> 7.73	0.116	37.7	73.9
Combined predictor	0.887	< 0.001	0.837–0.937	> 0.309	0.631	77.4	85.7

ROC receiver operating characteristic, ICU intensive care unit, NK natural killer, IL interleukin, TNF tumor necrosis factor, IFN interferon

ISSN: 1743-422X