Table 3 Comparison of lymphocyte subsets and cytokines between non-ICU and ICU groups on hospital admission
From: Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19
Characteristic | Normal range | Total (n = 214) | Non- ICU group (n = 161) | ICU group (n = 53) | P value |
|---|---|---|---|---|---|
Lymphocyte classification | Â | Â | Â | Â | Â |
Lymphocyte, median (IQR), × 106/L | 1530.00–3700.00 | 936.50 (661.50–1323.25) | 1063.00 (767.50–1389.50) | 659.00 (480.50–885.50) |  < 0.001 |
CD3+, median (IQR), × 106/L | 699.00–2540.00 | 632.50 (429.50–925.50) | 717.00 (544.00–973.00) | 417.00 (252.50–571.50) |  < 0.001 |
CD4+, median (IQR), × 106/L | 410.00–1590.00 | 377.50 (265.75–536.00) | 432.00 (308.50–609.50) | 261.00 (153.50–351.50) |  < 0.001 |
CD8+, median (IQR), × 106/L | 190.00–1140.00 | 242.50 (157.75–335.50) | 271.00 (193.00–382.50) | 140.00 (95.00–205.00) |  < 0.001 |
CD19+, median (IQR), × 106/L | 90.00–660.00 | 128.00 (86.75–184.75) | 133.00 (90.50–209.00) | 109.00 (77.50–144.50) | 0.012 |
NK, median (IQR), × 106/L | 90.00–590.00 | 132.00 (86.75–211.00) | 143.00 (96.50–230.50) | 102.00 (65.50–166.00) | 0.002 |
CD3+, median (IQR),% | 55.00–84.00 | 68.09 (61.74–75.00) | 70.26 (64.23–75.48) | 62.59 (54.61–68.75) |  < 0.001 |
CD4+, median (IQR),% | 31.00–60.00 | 39.30 (34.58–44.40) | 40.05 (35.87–44.93) | 37.78 (29.18–43.56) | 0.030 |
CD8+, median (IQR),% | 13.00–41.00 | 25.02 (20.28–30.41) | 25.96 (21.03–30.75) | 22.42 (17.52–29.01) | 0.009 |
CD19+, median (IQR),% | 6.00–25.00 | 14.54 (10.46–18.09) | 13.94 (9.99–17.14) | 17.48 (13.29–22.21) |  < 0.001 |
NK, median (IQR),% | 5.00–27.00 | 15.00 (9.59–21.97) | 13.98 (9.11–20.85) | 18.64 (10.10–25.99) | 0.038 |
CD4+/CD8+, median (IQR) | 0.70–2.87 | 1.54 (1.20–2.05) | 1.54 (1.24–1.97) | 1.53 (1.12–2.43) | 0.649 |
Cytokine profiles | Â | Â | Â | Â | Â |
IL-4, median (IQR), pg/mL | 0.00–8.56 | 1.70 (1.33–2.38) | 1.70 (1.34–2.37) | 1.68 (1.26–2.45) | 0.573 |
IL-6, median (IQR), pg/mL | 0.00–5.40 | 4.15 (0.00–11.75) | 3.13 (0.00–6.69) | 18.08 (6.69–46.45) |  < 0.001 |
IL-10, median (IQR), pg/mL | 0.00–12.90 | 2.72 (2.33–3.76) | 2.56 (2.23–3.08) | 3.83 (2.98–5.16) |  < 0.001 |
IL-17, median (IQR), pg/mL | 0.00–21.40 | 1.21 (1.04–1.38) | 1.21 (1.04–1.39) | 1.18 (1.02–1.37) | 0.393 |
TNF-α, median (IQR), pg/mL | 0.00–16.50 | 3.39 (1.82–5.93) | 3.48 (1.86–6.25) | 3.05 (1.61–5.42) | 0.390 |
IFN-γ, median (IQR), pg/mL | 0.00–23.10 | 4.15 (1.77–8.28) | 4.05 (1.70–7.88) | 4.32 (2.32–8.72) | 0.295 |