Table 7 Effect of Amino-acid substution on T-cell epitopes of HPV-16 E6
From: The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China
Substution | HPV-16 E6 | ||
|---|---|---|---|
Epitopes | Alles | Effection | |
M1K | 1-9KHQKRTAMF | HLA-A*24:02 | Better affinity |
R17G | 13-22QERPGKLPQL | HLA-B*40:01 | Better affinity |
9-19FQDPQERPGKL | HLA-B*13:01 | ||
9-19FQDPQERPGKL | HLA-C*08:01 | Affinity decreased | |
8-17MFQDPQERPR | HLA-A*33:03 | Disappear | |
17-26RKLPQLCTEL | HLA-C*01:02 | ||
9-19FQDPQERPRKL | HLA-C*03:04 | ||
7-17AMFQDPQERPR | HLA-A*33:03 | ||
D32E | 26-34LQTTIHEII | HLA-B*13:01 | Better affinity |
29-39TIHEIILECVY | HLA-B*15:02 | Affinity decreased | |
29-37TIHEIILEC | HLA-A*02:01 | ||
29-38TIHEIILECV | HLA-A*02:01 | ||
24-33TELQTTIHEI | HLA-B*40:01 | New epitopes | |
25-33ELQTTIHEI | HLA-B*13:01 | ||
32-39EIILECVY | HLA-B*15:02 | ||
25-33ELQTTIHEI | HLA-A*02:01 | ||
31-39HEIILECVY | HLA-B*15:02 | ||
26-33LQTTIHEI | HLA-B*13:01 | ||
29-39TIHDIILECVY | HLA-B*46:01 | Disappear | |
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*02:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*02:01 | ||
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*05:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*02:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*05:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*05:01 | ||
D32N | 26-34LQTTIHNII | HLA-B*13:01 | Better affinity |
24-35TELQTTIHNIIL | HLA-B*40:01 | ||
24-33TELQTTIHNI | HLA-B*40:01 | New epitopes | |
27-35QTTIHNIIL | HLA-C*03:04 | ||
29-39TIHDIILECVY | HLA-B*15:02 | Disappear | |
29-37TIHDIILEC | HLA-A*02:01 | ||
D32N | 29-38TIHDIILECV | HLA-A*02:01 | Disappear |
29-39TIHDIILECVY | HLA-B*46:01 | ||
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*02:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*02:01 | ||
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*05:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*02:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*05:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*05:01 | ||
I34R | 29-39TIHDIRLECVY | HLA-B*15:02 | Better affinity |
29-39TIHDIRLECVY | HLA-B*46:01 | Affinity decreased | |
24-35TELQTTIHDIRL | HLA-B*40:01 | ||
25-34ELQTTIHDIR | HLA-A*33:03 | New epitopes | |
29-37TIHDIILEC | HLA-A*02:01 | Disappear | |
26-34LQTTIHDII | HLA-B*13:01 | ||
29-38TIHDIILECV | HLA-A*02:01 | ||
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*02:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*02:01 | ||
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*05:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*02:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*05:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*05:01 | ||
L35V | 29-39TIHDIIVECVY | HLA-B*15:02 | Better affinity |
29-38TIHDIIVECV | HLA-A*02:01 | ||
29-39TIHDIIVECVY | HLA-B*46:01 | ||
29-37TIHDIIVEC | HLA-A*02:01 | ||
35-45VECVYCKQQLL | HLA-B*40:01 | New epitopes | |
24-35TELQTTIHDIIL | HLA-B*40:01 | Disappear | |
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*02:01 | ||
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*02:01 | ||
25-39ELQTTIHDIILECVY | HLA-DQA1*01:01/DQB1*05:01 | ||
26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*02:01 | ||
L35V | 26-40LQTTIHDIILECVYC | HLA-DQA1*01:01/DQB1*05:01 | Disappear |
24-38TELQTTIHDIILECV | HLA-DQA1*01:01/DQB1*05:01 | ||
P66A | 59-67IVYRDGNAY | HLA-B*15:02 | Better affinity |
59-67IVYRDGNAY | HLA-B*46:01 | ||
59-67IVYRDGNAY | HLA-C*03:02 | ||
66-76AYAVCDKCLKF | HLA-A*24:02 | ||
61-69YRDGNAYAV | HLA-A*11:01 | Affinity decreased | |
59-67IVYRDGNAY | HLA-C*08:01 | ||
56-67DLCIVYRDGNAY | HLA-B*15:02 | New epitopes | |
57-67LCIVYRDGNAY | HLA-B*46:01 | ||
60-67VYRDGNAY | HLA-B*15:02 | ||
58-67CIVYRDGNAY | HLA-B*15:02 | ||
57-67LCIVYRDGNAY | HLA-B*15:02 | ||
60-69VYRDGNPYAV | HLA-A*24:02 | Disappear | |
H85Y | 85-95YYCYSLYGTTL | HLA-A*24:02 | Better affinity |
77-86YSKISEYRYY | HLA-B*46:01 | ||
82-96EYRYYCYSLYGTTLE | HLA-DRB1*15:02 | ||
80-94ISEYRYYCYSLYGTT | HLA-DRB1*15:02 | ||
79-93KISEYRYYCYSLYGT | HLA-DRB1*15:02 | ||
81-95SEYRYYCYSLYGTTL | HLA-DRB1*15:02 | ||
78-92SKISEYRYYCYSLYG | HLA-DRB1*15:02 | ||
83-97YRYYCYSLYGTTLEQ | HLA-DRB1*15:02 | ||
77-91YSKISEYRYYCYSLY | HLA-DRB1*15:02 | ||
82-96EYRYYCYSLYGTTLE | HLA-DPA1*01:03/DPB1*04:01 | ||
83-97YRYYCYSLYGTTLEQ | HLA-DPA1*01:03/DPB1*04:01 | ||
77-85YSKISEYRY | HLA-C*03:02 | New epitopes | |
77-85YSKISEYRY | HLA-B*46:01 | ||
77-85YSKISEYRY | HLA-B*15:02 | ||
77-85YSKISEYRY | HLA-B*58:01 | ||
77-86YSKISEYRYY | HLA-C*03:02 | ||
76-85FYSKISEYRY | HLA-A*24:02 | ||
H85Y | 80-94ISEYRYYCYSLYGTT | HLA-DPA1*01:03/DPB1*04:01 | New epitopes |
84-98RYYCYSLYGTTLEQQ | HLA-DPA1*01:03/DPB1*04:01 | ||
79-93KISEYRYYCYSLYGT | HLA-DPA1*01:03/DPB1*04:01 | ||
85-99YYCYSLYGTTLEQQY | HLA-DPA1*01:03/DPB1*04:01 | ||
84-98RYYCYSLYGTTLEQQ | HLA-DRB1*15:02 | ||
85-99YYCYSLYGTTLEQQY | HLA-DRB1*15:02 | ||
72-86KCLKFYSKISEYRYY | HLA-DRB1*12:02 | ||
81-95SEYRYYCYSLYGTTL | HLA-DPA1*01:03/DPB1*04:01 | ||
81-90SEYRYYCYSL | HLA-B*40:01 | Affinity decreased | |
82-90EYRYYCYSL | HLA-A*24:02 | ||
80-88ISEYRHYCY | HLA-C*03:02 | Disappear | |
77-86YSKISEYRHY | HLA-C*03:02 | ||
76-86FYSKISEYRHY | HLA-A*24:02 | ||
L90V | 86-95YCYSVYGTTL | HLA-C*03:04 | Better affinity |
88-95YSVYGTTL | HLA-C*01:02 | ||
88-95YSVYGTTL | HLA-C*03:02 | ||
88-95YSVYGTTL | HLA-C*03:04 | ||
85-95HYCYSVYGTTL | HLA-A*24:02 | ||
89-99SVYGTTLEQQY | HLA-B*46:01 | ||
89-101SVYGTTLEQQYNK | HLA-A*11:01 | ||
86-95YCYSVYGTTL | HLA-A*24:02 | ||
87-95CYSVYGTTL | HLA-A*24:02 | ||
89-99SVYGTTLEQQY | HLA-A*11:01 | ||
89-99SVYGTTLEQQY | HLA-C*03:02 | New epitopes | |
89-97SVYGTTLEQ | HLA-A*11:01 | ||
89-99SVYGTTLEQQY | HLA-B*15:02 | Affinity decreased | |
82-90EYRHYCYSL | HLA-A*24:02 | Disappear | |
81-90SEYRHYCYSL | HLA-B*40:01 | ||
82-96EYRHYCYSLYGTTLE | HLA-DPA1*01:03/DPB1*04:01 | ||
83-97YRHYCYSLYGTTLEQ | HLA-DPA1*01:03/DPB1*04:01 | ||
E120D | 118-126CPDEKQRHL | HLA-C*08:01 | New epitopes |
E120D | 118-126CPDEKQRHL | HLA-C*03:04 | New epitopes |
R151T | 150-158STTRRETQL | HLA-C*01:02 | New epitopes |
144-154MSCCRSSTTRR | HLA-A*33:03 | ||
150-158STTRRETQL | HLA-C*03:04 | ||