Table 10 Effect of Amino-acid substution on T-cell epitopes of HPV-52 E6
From: The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China
Substution | HPV-52 E6 | ||
|---|---|---|---|
Epitopes | Alles | Effection | |
E21K | 17-27EVLEKSVHEIR | HLA-A*33:03 | Better affinity |
18-26VLEKSVHEI | HLA-B*13:01 | Affinity decreased | |
18-26VLEKSVHEI | HLA-A*02:01 | ||
19-28LEKSVHEIRL | HLA-B*40:01 | ||
18-26VLEKSVHEI | HLA-C*08:01 | ||
18-26VLEKSVHEI | HLA-C*01:02 | ||
19-26LEKSVHEI | HLA-B*40:01 | ||
10-21RTLHELCEVLEK | HLA-A*11:01 | New epitopes | |
20-28EESVHEIRL | HLA-B*40:01 | Disappear | |
82-93SLYGKTLEERVK | HLA-A*11:01 | ||
18-28VLEESVHEIRL | HLA-A*02:01 | ||
9-23PRTLHELCEVLEESV | HLA-DQA1*01:01/DQB1*02:01 | ||
10-24RTLHELCEVLEESVH | HLA-DQA1*01:01/DQB1*02:01 | ||
L46V | 46-55VFTDLRIVYR | HLA-A*33:03 | Better affinity |
42-51VYKFVFTDLR | HLA-A*33:03 | ||
45-55FVFTDLRIVYR | HLA-A*33:03 | ||
41-51EVYKFVFTDLR | HLA-A*33:03 | ||
45-54FVFTDLRIVY | HLA-B*46:01 | ||
40-47REVYKFVF | HLA-B*40:01 | ||
46-54VFTDLRIVY | HLA-B*46:01 | ||
42-50VYKFVFTDL | HLA-A*24:02 | ||
45-54FVFTDLRIVY | HLA-C*03:02 | ||
46-54VFTDLRIVY | HLA-C*03:02 | ||
45-54FVFTDLRIVY | HLA-B*15:02 | Affinity decreased | |
44-52KFVFTDLRI | HLA-A*24:02 | ||
45-53FVFTDLRIV | HLA-A*02:01 | ||
41-55EVYKFVFTDLRIVYR | HLA-DPA1*01:03/DPB1*04:01 | ||
39-53RREVYKFVFTDLRIV | HLA-DPA1*01:03/DPB1*04:01 | ||
43-57YKFVFTDLRIVYRDN | HLA-DPA1*01:03/DPB1*04:01 | ||
38-52QRREVYKFVFTDLRI | HLA-DPA1*01:03/DPB1*04:01 | ||
37-51LQRREVYKFVFTDLR | HLA-DPA1*01:03/DPB1*04:01 | ||
L46V | 44-58KFVFTDLRIVYRDNN | HLA-DPA1*01:03/DPB1*04:01 | Affinity decreased |
36-50ELQRREVYKFVFTDL | HLA-DPA1*01:03/DPB1*04:01 | ||
41-55EVYKFVFTDLRIVYR | HLA-DRB1*14:01 | ||
42-56VYKFVFTDLRIVYRD | HLA-DRB1*14:01 | ||
43-57YKFVFTDLRIVYRDN | HLA-DRB1*14:01 | ||
40-54REVYKFVFTDLRIVY | HLA-DRB1*14:01 | ||
41-55EVYKFVFTDLRIVYR | HLA-DRB1*12:02 | ||
46-54VFTDLRIVY | HLA-A*24:02 | New epitopes | |
40-50REVYKFVFTDL | HLA-B*40:01 | ||
45-53FVFTDLRIV | HLA-B*46:01 | ||
45-53FVFTDLRIV | HLA-C*03:02 | ||
45-53FVFTDLRIV | HLA-C*03:04 | ||
40-54REVYKFLFTDLRIVY | HLA-DQA1*01:01/DQB1*05:01 | Disappear | |
39-53RREVYKFLFTDLRIV | HLA-DQA1*01:01/DQB1*05:01 | ||
41-55EVYKFLFTDLRIVYR | HLA-DQA1*01:01/DQB1*05:01 | ||
42-56VYKFLFTDLRIVYRD | HLA-DQA1*01:01/DQB1*05:01 | ||
42-56VYKFLFTDLRIVYRD | HLA-DRB1*12:02 | ||
40-54REVYKFLFTDLRIVY | HLA-DQA1*01:01/DQB1*02:01 | ||
41-55EVYKFLFTDLRIVYR | HLA-DQA1*01:01/DQB1*02:01 | ||
40-54REVYKFLFTDLRIVY | HLA-DRB1*12:02 | ||
44-58KFLFTDLRIVYRDNN | HLA-DRB1*14:01 | ||
43-57YKFLFTDLRIVYRDN | HLA-DRB1*12:02 | ||
E89K | 82-92SLYGKTLKERV | HLA-A*02:01 | Affinity decreased |
86-94KTLKERVKK | HLA-A*11:01 | ||
85-94GKTLKERVKK | HLA-A*11:01 | ||
82-93SLYGKTLKERVK | HLA-A*11:01 | ||
41-55EVYKFVFTDLRIVYR | HLA-DPA1*01:03/DPB1*04:01 | ||
39-53RREVYKFVFTDLRIV | HLA-DPA1*01:03/DPB1*04:01 | ||
43-57YKFVFTDLRIVYRDN | HLA-DPA1*01:03/DPB1*04:01 | ||
38-52QRREVYKFVFTDLRI | HLA-DPA1*01:03/DPB1*04:01 | ||
37-51LQRREVYKFVFTDLR | HLA-DPA1*01:03/DPB1*04:01 | ||
E89K | 44-58KFVFTDLRIVYRDNN | HLA-DPA1*01:03/DPB1*04:01 | Affinity decreased |
36-50ELQRREVYKFVFTDL | HLA-DPA1*01:03/DPB1*04:01 | ||
42-56VYKFVFTDLRIVYRD | HLA-DRB1*14:01 | ||
41-55EVYKFVFTDLRIVYR | HLA-DRB1*14:01 | ||
43-57YKFVFTDLRIVYRDN | HLA-DRB1*14:01 | ||
40-54REVYKFVFTDLRIVY | HLA-DRB1*14:01 | ||
41-55EVYKFVFTDLRIVYR | HLA-DRB1*12:02 | ||
82-91SLYGKTLKER | HLA-A*11:01 | Better affinity | |
82-91SLYGKTLKER | HLA-A*33:03 | ||
75-89EYRHYQYSLYGKTLK | HLA-DPA1*01:03/DPB1*04:01 | ||
81-89YSLYGKTLK | HLA-A*11:01 | New epitopes | |
79-89YQYSLYGKTLK | HLA-A*11:01 | ||
80-89QYSLYGKTLK | HLA-A*11:01 | ||
82-94SLYGKTLEERVKK | HLA-A*11:01 | Disappear | |
84-94YGKTLEERVKK | HLA-A*11:01 | ||
40-54REVYKFLFTDLRIVY | HLA-DQA1*01:01/DQB1*05:01 | ||
39-53RREVYKFLFTDLRIV | HLA-DQA1*01:01/DQB1*05:01 | ||
41-55EVYKFLFTDLRIVYR | HLA-DQA1*01:01/DQB1*05:01 | ||
42-56VYKFLFTDLRIVYRD | HLA-DQA1*01:01/DQB1*05:01 | ||
42-56VYKFLFTDLRIVYRD | HLA-DRB1*12:02 | ||
40-54REVYKFLFTDLRIVY | HLA-DQA1*01:01/DQB1*02:01 | ||
41-55EVYKFLFTDLRIVYR | HLA-DQA1*01:01/DQB1*02:01 | ||
40-54REVYKFLFTDLRIVY | HLA-DRB1*12:02 | ||
44-58KFLFTDLRIVYRDNN | HLA-DRB1*14:01 | ||
43-57YKFLFTDLRIVYRDN | HLA-DRB1*12:02 | ||
K93R | 85-94GKTLEERVRK | HLA-A*11:01 | Affinity decreased |
82-94SLYGKTLEERVRK | HLA-A*11:01 | ||
84-94YGKTLEERVRK | HLA-A*11:01 | ||
88-96LEERVRKPL | HLA-B*40:01 | ||
82-93SLYGKTLEERVR | HLA-A*33:03 | New epitopes | |
91-99RVKKPLSEI | HLA-B*13:01 | Disappear | |
K93R | 82-93SLYGKTLEERVK | HLA-A*11:01 | Disappear |
I105M | 97-105SEITIRCIM | HLA-B*40:01 | Better affinity |
N122K | 120-128NANKRFHNI | HLA-C*08:01 | Disappear |
120-128NANKRFHNI | HLA-C*03:04 | ||
N127I | 127-135IIMGRWTGR | HLA-A*33:03 | Affinity decreased |
124-132RFHIIMGRW | HLA-A*24:02 | ||
126-135HIIMGRWTGR | HLA-A*33:03 | Better affinity | |
125-135FHIIMGRWTGR | HLA-A*33:03 | ||
120-128NANKRFHII | HLA-C*03:04 | ||
120-128NANKRFHII | HLA-C*08:01 | ||
120-131NANKRFHIIMGR | HLA-A*33:03 | New epitopes | |
121-135ANKRFHIIMGRWTGR | HLA-DRB1*12:02 | ||
123-137KRFHIIMGRWTGRCS | HLA-DRB1*12:02 | ||
122-136NKRFHIIMGRWTGRC | HLA-DRB1*12:02 | ||
120-134NANKRFHIIMGRWTG | HLA-DRB1*12:02 | ||
119-133VNANKRFHIIMGRWT | HLA-DRB1*12:02 | ||
124-138RFHIIMGRWTGRCSE | HLA-DRB1*12:02 | ||
124-132RFHNIMGRW | HLA-B*58:01 | Disappear | |
E138K | 132-140WTGRCSKCW | HLA-B*58:01 | Affinity decreased |