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Table 1 Clinical characteristics of invasively ventilated hospitalized children with human adenovirus pneumonia

From: Viral loads in nasopharyngeal aspirates and tracheal aspirates among children hospitalized with invasive ventilation for human adenovirus pneumonia

Characteristics

All patients

HAdV-7 infected

Other HAdV types infected

Single HAdV-7 infected

Single other HAdV types infected

(n = 94)

(n = 78)

(n = 16)

(n = 59)

(n = 13)

No. (%)

No. (%)

No. (%)

No. (%)

No. (%)

Gender (male)

64 (68.09)

50 (64.10)

14 (87.50)

36 (61.02)

12 (92.31)b

Age (months), median (IQR)

12 (11.00, 24.00)

12 (10.75, 24.00)

12 (11.25, 33.50)

12 (11.00,24.00)

12 (9.00, 25.00)

 < 6

3 (3.19)

2 (2.56)

1 (6.25)

1 (1.69)

1 (7.69)

6–11

26 (27.66)

23 (29.49)

3 (18.75)

17 (28.81)

3 (23.08)

12–35

49 (52.13)

41 (52.56)

8 (50.00)

34 (57.63)

7 (53.85)

36–59

12 (12.77)

9 (11.54)

3 (18.75)

6 (10.17)

2 (15.38)

 ≥ 60

4 (4.26)

3 (3.85)

1 (6.25)

1 (1.69)

0

Clinical features

Duration of onset (days), median (IQR)

6.00 (4.00, 8.25)

6.00 (4.00, 10.00)

5.50 (4.00, 8.00)

6.00 (4.00, 7.00)

5.00 (4.00, 7.00)

Fever

94 (100.00)

78 (100.00)

16 (100.00)

59 (100.00)

13 (100.00)

Tmax (°C), median (IQR)

39.8 (39.5, 40.1)

39.8 (39.5, 40.0)

39.8 (39.2, 40.3)

39.80 (39.50,40.00)

39.70 (39.40, 40.30)

Duration of fever (days), median (IQR)

17.50 (13.00, 24.00)

19.00 (13.75, 25.00)

15.50 (11.25, 17.00)a

19.00 (14.00,25.00)

15.00 (11.00, 18.50)b

Cough

94 (100.00)

78 (100.00)

16 (100.00)

59 (100.00)

13 (100.00)

Wheezing

31 (32.98)

28 (35.90)

3 (18.75)

24 (40.68)

4 (30.77)

Diarrhea

8 (8.51)

7 (8.97)

1 (6.25)

7 (11.86)

1 (7.69)

Vomiting

10 (10.64)

10 (12.82)

0

9 (15.25)

1 (7.69)

Underlying diseases

3 (3.19)

2 (2.56)

1 (6.25)

3 (5.08)

0

BPD

1 (1.06)

1 (1.28)

0

1 (1.69)

0

Hemodynamically significant heart disease

2 (2.13)

1 (1.28)

1 (6.25)

2 (3.39)

0

Clinical outcomes

Duration of onset to intubation (days), median (IQR)

8.00 (7.00, 9.00)

8.00 (7.00, 10.00)

7.00 (6.00, 8.00)

8.00 (7.00, 10.00)

7.00 (6.00, 7.50)b

Duration of mechanical ventilation (days), median (IQR)

10.00 (8.00, 14.00)

10.50 (9.00, 14.25)

8.50 (7.00, 11.00)a

11.00 (9.00, 15.00)

9.00 (7.00, 13.00)

LOS in PICU (days), median (IQR)

17.00 (13.00, 23.00)

17.00 (14.00, 23.00)

13.00 (10.00, 18.00)a

17.00 (14.00, 23.00)

14.00 (12.00, 18.00)b

LOS in hospital (days), median (IQR)

26.00 (20.00, 33.00)

27.00 (21.00, 33.00)

19.50 (17.00, 25.00)a

27.00 (20.00, 33.00)

24.00 (17.50, 25.00)b

Death

5 (5.32)

5 (6.41)

0

4 (6.78)

0

Co-infected

22 (23.40)

19 (26.39)

3 (13.64)

  
  1. Other HAdV types of children, 12 were HAdV-3, 2 were HAdV-2, 1 was HAdV-4, and 1 was HAdV-14. n indicates the patient’s number. LOS indicates the length of stay. PICU indicates pediatric intensive care unit. BPD indicates bronchopulmonary dysplasia
  2. HAdV-7 infected group is the children infected by HAdV-7. Other types infected group is the children infected by adenovirus types 2, 3, 4, 14. Single HAdV-7 infections and single other types infections group are the children only infected by HAdV-7 or other HAdV types. Continuous variables were described by median and 25th and 75th interquartile range (IQR). Comparisons between types of infection, as defined by these groups, were made using χ2 tests or the Fisher exact test as appropriate for categorical variables and the Wilcoxon rank-sum test as appropriate for continuous variables
  3. aP < 0 .05, for comparison of HAdV-7 infected to other HAdV types infected
  4. bP < 0.05, for comparison of single HAdV-7 infected to single other HAdV types infected
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Virology Journal

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