Fig. 3

Comparative analysis of the potential NAs-resistant mutations in RT region and the mutation rates of single amino acid site in Core and PreS2 regions. Dynamic changes of the indel mutation rates in Core and RT regions of HBV genome from mothers and infants at 7 months and 3 years old. (A) The cumulative rate of NAs-resistant mutations in RT region of HBV genome from mothers and infants at 7 months and 3 years old. (B) The ratio of clones with NAs-resistant mutations in RT region of HBV genome from mothers and infants at 7 months and 3 years old. (C) The single amino acid site mutation rate in Core and PreS2 region of all clones from mothers and infants at 7 months and 3 years old. (D) Black line represents the data from mothers, light blue line for 7-month-old infants and dark blue line for 3-year-old infants. Sites with mutation rate > 1% in Core region and sites with mutation rate > 0.5% in PreS2 region were noted. All the mutations were defined based on a same consensus sequence synthesized by all clones from mothers