Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma: current challenges and opportunities

Table 2 Frequency of HPV16 variants

Reference	Total cases HPV16 detected (n)	Total isolates HPV sequencing (n)	HPV16 variant region location	European (E)		North American	African	Asian	Asia American
Reference	Total cases HPV16 detected (n)	Total isolates HPV sequencing (n)	HPV16 variant region location	All lineages (n)	E-350-G (n)	(NA) (n)	(AF1\|AF2) (n)	(AS) (n)	(AA) (n)
[48]	56	52	E6	39	6	2	2	9	0
[49]	24	21	E6 E7	15	8	0	0	0	0
[50]	14	13	L1	9	0	1	2	0	1
[51]	44	19	E6	18	4	0	0	1	0
[52]	8	8	E6	5	5	0	0	0	0
[53]	4	4	E6	2	1	0	0	0	2
[54]	10	10	E6	8	8	0	0	0	0
[55]	25	21	LCR	9	–	0	0	0	12
[56]	17	13	E6	11	–	0	0	0	2

(–) not evaluated; AA Asia-American HPV16 Variant; AF African HPV16 Variant; AS Asian HPV16 variant; E European HPV16 variant; E6 HPV Early protein 6; E7 HPV Early protein 7; LCR long control region; L1 late gene; NA North American HPV16 Variant

ISSN: 1743-422X