Fig. 2
From: Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice
Elevated expression of IL-38 and IL-36R in AVMC. A Representative images of IL-38 immunohistochemistry of heart tissue from the control (n = 10) and AVMC (n = 13) groups (Brown granules, magnification × 400). B Morphometric quantitation of cardiac IL-38 protein expression. C ELISA analysis of serum IL-38 levels. D Relative cardiac mRNA expression of IL-38 and IL-36R detected by RT-qPCR. E–F Negative association of cardiac IL-38 mRNA expression with bodyweight loss and cardiac pathological scores on day 7 post-infection. Each point represents an individual mouse. G–H Negative association of serum IL-38 levels with bodyweight loss and cardiac pathological scores on day 7 post-infection. Each point represents an individual mouse. **P < 0.01, compared to control group. Data are expressed as mean ± SD