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Table 5 SARS-CoV-2 variants of concern (as of July 22, 2021)

From: Evolutionary trajectory of SARS-CoV-2 and emerging variants

Variant Mutations of interest Clade Date of emergence First detection in human population Country of likely origin References
B.1.1.7 (VOC2020 12/01, 501.V1, Alpha) S: 69-70del
S: Y144del
S: N501Y
S: D614G
S: P681H
GRY September, 2020 December, 2020 United Kingdom [89, 99, 190]
B.1.351 (501.V2, Beta) S: K417N
S: E484K
S: N501Y
S: D614G
S: A701V
GH October, 2020 December, 2020 South Africa [100, 101, 190]
P.1 (501.V3, Gamma) S: K417T
S: E484K
S: N501Y
S: D614G
GR July, 2020 January, 2021 Brazil [101, 190, 194]
B.1.617.2 (Delta) S: L452R
S: T478K
S: D614G
S: P681R
G October, 2020 December, 2020 India [196, 201, 202, 346]
  1. Variant names are based on Rambaut et al.’s classification [347]. Other commonly used names are mentioned in brackets. Mutations mentioned here are non-synonymous mutations that are speculated to confer some functional significance. These variants contain other mutations that may also contribute to viral advantages [89, 99,100,101]. Updated information about SARS-CoV-2 VOCs can be accessed through the GISAID resource (https://www.gisaid.org). Dates of emergence are based on retrospective analyses. S, spike. del, deletion