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Fig. 3 | Virology Journal

Fig. 3

From: Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

Fig. 3

HPV16 E6 and E7 stimulates the transcriptional activity of the MCPyV early and late promoter. A C33A cells were transfected with 400 ng luciferase reporter plasmid and increasing amounts (400 ng or 800 ng) of expression plasmids for HPV16 E6 and E7. B HSC-3 cells were transfected with 400 ng luciferase reporter plasmid and increasing amounts of expression plasmids for HPV16 E6 and E7. C HaCaT cells were transfected with 400 ng luciferase reporter plasmid and increasing amounts of expression plasmids for HPV16 E6 and E7. Luciferase activity was corrected for the protein concentration in each sample. Each bar represents the average of three independent parallels ± SD. The transcriptional activity of the early (respectively late) promoter in the presence of empty vector pcDNA3.1 (EV) was arbitrary set as 100%. Similar results were obtained in an independent experiment. *p < 0.05; **p < 0.01; ***p < 0.001

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Virology Journal

ISSN: 1743-422X