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Fig. 2 | Virology Journal

Fig. 2

From: Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

Fig. 2

MCPyV LT and sT transactivate the transcriptional activity of HPV16 LCR and HPV18 LCR. A C33A cells were transfected with 400 ng luciferase reporter plasmid and increasing amounts (200 ng, 400 ng, or 800 ng) of expression plasmids for MCPyV LT or sT. B HSC-3 cells were transfected with increasing amounts of expression plasmids for MCPyV LT or sT. C HaCaT cells were transfected with increasing amounts of expression plasmids for MCPyV LT or sT. Luciferase activity was corrected for the protein concentration in the lysate. Each bar represents the average of three independent parallels ± SD. The transcriptional activity of the HPV16 LCR (respectively HPV18 LCR) in the presence of empty vector pcDNA3.1 (EV) was arbitrary set as 100%. Similar results were obtained in an independent experiment. *p < 0.05; **p < 0.01; ***p < 0.001

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Virology Journal

ISSN: 1743-422X