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Table 1 Summary of the effects of amino acids on virus attachment/entry

From: The key amino acids of E protein involved in early flavivirus infection: viral entry

Amino acids Amino acid localization Structural position/functional site Viruses References
154 (DENV, 153) Domain I Glycosylation site DENV, WNV, JEV, ZIKV [44,45,46,47]
398, 405, 429, 436 Stem region α-helix in stem region DENV [48]
424–445 Stem region Stem region ZIKA [49]
138 Domain I Virulence attenuated site JEV [50,51,52,53]
390 Domain III RGD motif MVE [54]
277 Between domain I & domain II Hinger region MVE [55]
325, 380 Domain III Top layer of virion YFV [56, 57]
19–22 Domain I HspA9 binding motif TMUV [58]
245–252 Domain II
304 Domain III Virulence attenuated site TMUV [59]
367 Domain III Virulence attenuated site TMUV [60]
144 Domain I Participating domain I-domain III interaction JEV [61]
319 Domain III
258 Domain II Potentially participating post-fusion step
410 Domain III
291 Domain III Participate in electrostatically mediated interactions DENV [62]
  1. The table counts the amino acids known to affect the early life cycle of flavivirus E protein. Meanwhile, the structural positions and potential functions of these amino acids are also displayed