The key amino acids of E protein involved in early flavivirus infection: viral entry

Table 1 Summary of the effects of amino acids on virus attachment/entry

Amino acids	Amino acid localization	Structural position/functional site	Viruses	References
154 (DENV, 153)	Domain I	Glycosylation site	DENV, WNV, JEV, ZIKV	[44,45,46,47]
398, 405, 429, 436	Stem region	α-helix in stem region	DENV	[48]
424–445	Stem region	Stem region	ZIKA	[49]
138	Domain I	Virulence attenuated site	JEV	[50,51,52,53]
390	Domain III	RGD motif	MVE	[54]
277	Between domain I & domain II	Hinger region	MVE	[55]
325, 380	Domain III	Top layer of virion	YFV	[56, 57]
19–22	Domain I	HspA9 binding motif	TMUV	[58]
245–252	Domain II	HspA9 binding motif	TMUV	[58]
304	Domain III	Virulence attenuated site	TMUV	[59]
367	Domain III	Virulence attenuated site	TMUV	[60]
144	Domain I	Participating domain I-domain III interaction	JEV	[61]
319	Domain III	Participating domain I-domain III interaction
258	Domain II	Potentially participating post-fusion step
410	Domain III	Potentially participating post-fusion step
291	Domain III	Participate in electrostatically mediated interactions	DENV	[62]
295	Domain III	Participate in electrostatically mediated interactions	DENV	[62]

The table counts the amino acids known to affect the early life cycle of flavivirus E protein. Meanwhile, the structural positions and potential functions of these amino acids are also displayed

ISSN: 1743-422X