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Table 1 The sensitivity and specificity of direct RT-qPCR on self-collected nasal swabs in samples with clear SARS-CoV-2 positivity (Ct < 37) detected by two-step RT-qPCR on nasopharyngeal swabs

From: Excellent option for mass testing during the SARS-CoV-2 pandemic: painless self-collection and direct RT-qPCR

 

Two-step RT-qPCR on nasopharyngeal swabs

Positive#

Negative

Total

Direct RT-qPCR on nasal swab

   

Positive

246

3*

249

Negative

13

776

789

Total

259

779

1038

Sensitivity

94.98% (95% CI 91.57–97.30%)

  

Specificity

99.61% (95% CI 98.88–99.92%)

  

Positive predictive value (PPV)

98.80% (95% CI 96.36–99.61%)

  

Negative predictive value (NPV)

98.73% (95% CI 97.23–99.02%)

  
  1. #RT-qPCR positivity is defined as having Ct values lower than or equal to 37
  2. *Direct RT-qPCR positivity for these nasal-swab samples was confirmed by two-step RT-qPCR from RNA isolates
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Virology Journal

ISSN: 1743-422X