Antibody
|
Groupa
|
Contact with N501
|
Structure
|
References
|
Neutralization (IC50, µg/ml, mean)b
|
Affinity (KD, nM, mean)c
|
---|
WT
|
N501Y
|
FCd
|
WT
|
N501Y
|
FCd
|
---|
P2C-1F11
|
Class 1
|
No
|
PDB: 7CDI
|
Ge et al. [13]
|
0.0300
|
0.0180
|
0.60
|
0.526
|
0.241
|
0.46
|
REGN10933
|
Class 1
|
No
|
PDB: 6XDG
|
Hansen, et al.[3]
|
0.0015
|
0.0035
|
2.36
|
0.0645
|
0.123
|
1.91
|
CB6
|
Class 1
|
Yes
|
PDB: 7C01
|
Shi et al. [1]
|
0.0456
|
0.3363
|
7.38
|
0.321
|
2.14
|
6.67
|
BD-23
|
Class 2
|
Yes
|
PDB: 7BYR
|
Cao et al. [21]
|
16.3052
|
2.4771
|
0.15
|
137
|
20.6
|
0.15
|
P2B-2F6
|
Class 2
|
No
|
PDB: 7BWJ
|
Ju et al. [2]
|
0.1644
|
0.0697
|
0.42
|
0.667
|
0.267
|
0.40
|
P2C-1A3
|
Class 2
|
No
|
PDB: 7CDJ
|
Ge et al. [13]
|
0.1862
|
0.2833
|
1.52
|
0.247
|
0.167
|
0.68
|
BD-368–2
|
Class 2
|
No
|
PDB: 7CHH
|
Du et al. [15]
|
0.0004
|
0.0008
|
2.11
|
0.0649
|
0.0368
|
0.57
|
S309
|
Class 3
|
No
|
PDB: 6WPS
|
Pinto et al. [17]
|
0.1641
|
0.4307
|
2.62
|
< 0.001
|
< 0.001
|
n.a.e
|
REGN10987
|
Class 3
|
No
|
PDB: 6XDG
|
Hansen, et al.[3]
|
0.0062
|
0.0039
|
0.63
|
0.108
|
0.0587
|
0.54
|
EY6A
|
Class 4
|
No
|
PDB: 6ZDH
|
Zhou et al. [16]
|
7.0680
|
10.7957
|
1.53
|
0.111
|
0.134
|
1.21
|
COV2-2196
|
n.a
|
n.a
|
n.a
|
Zost et al. [4]
|
0.0032
|
0.0029
|
0.93
|
0.0681
|
0.0581
|
0.85
|
CV07-287
|
n.a
|
n.a
|
n.a
|
Kreye et al. [5]
|
0.2930
|
0.2610
|
0.89
|
1.19
|
1.25
|
1.05
|
- aAntibodies were classified into four groups based on their competitions with ACE2 and recognitions with ‘up’/‘down’ conformations of RBD [12]
- bNeutralization was measured as IC50 in µg/ml of nAbs against SARS-CoV-2 pseudovirus
- cAffinity was measured as KD in nM of nAbs binding to SARS-CoV-2 RBD by SPR
- dFC, Fold change. N501Y/WT
- en.a., not available