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Fig. 1 | Virology Journal

Fig. 1

From: When MARCH family proteins meet viral infections

Fig. 1

The antiviral functions of MARCH family proteins. a MARCH1/2 reduces envelope glycoproteins' incorporation into virions; MARCH1/2/8 target different viral proteins for degradation via lysosome or autophagosome pathway. b Mitochondria ubiquitin ligase MARCH5 targets HBV HBX to degradation via the proteasome pathway. c MARCH8 inhibits EBOV glycoprotein, HIV-1 envelope glycoprotein, and H5N1 hemagglutinin maturation and virions incorporation. HIV EnV: human immune deficiency virus envelope glycoprotein; PEDV NP: porcine epidemic-diarrhea virus nucleocapsid protein; EBOV GP: ebola virus glycoprotein; HBV HBX: hepatitis B viral × protein; H5N1 HA: influenza virus H5N1 hemagglutinin

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Virology Journal

ISSN: 1743-422X