Table 5 Summary of missense mutations on partial RdRP gene of SARS-CoV-2 and corresponding amino acid changes. Nucleotide and amino acid positions correspond to reference sequences NC_045512.2 and YP_009725307.1, respectively

15319C > T

P627S

1

^§End of conserved polymerase motif A (17/17), containing the classic divalent-cation-binding residue D618, related to RdRP fidelity

15327G > A

M629I

2

15327G > C

M629I

1

15327G > T

M629I

13

15328C > T

L630F

2

15338T > C

M633T

1

15346C > A

L636I

2

15346C > T

L636F

4

15349G > C

V637L

1

15352C > T

L638F

1

15356C > T

A639V

2

15358C > A

R640S

1

15359G > A

R640H

1

15364C > A

H642N

1

^§Zn binding site (6/8)

15368C > T

T643I

4

15371C > T

T644M

4

15380G > T

S647I

47

15384G > T

L648F

1

15392G > A

R651H

1

15406G > A

A656T

17

15406G > T

A656S

1

15407C > T

A656V

1

15412G > T

E658*

1

15418G > T

A660S

3

15438G > T

M666I

34

^§End of nsp8 interaction site (52/52)

15439G > A

V667I

5

15444G > T

M668I

3

15448G > A

G670S

1

15448G > T

G670C

1

15451G > A

G671S

2

15452G > T

G671V

2

15460T > C

Y674H

2

15463G > T

V675F

2

15472G > T

G678C

1

15488G > T

G683V

1

^§Conserved polymerase motif B (4/30), related to RdRP fidelity

15491A > G

D684G

1

^§Conserved polymerase motif B (5/30), related to RdRP fidelity

15535G > T

A699S

3

^§Conserved polymerase motif B (20/30), related to RdRP fidelity

15538G > A

V700I

1

^§Conserved polymerase motif B (21/30), related to RdRP fidelity

15539T > C

V700A

1

^§Conserved polymerase motif B (21/30), related to RdRP fidelity

15553A > G

N705D

1

^§Conserved polymerase motif B (26/30), related to RdRP fidelity

15571G > T

D711Y

1

15574G > A

G712S

1

15575G > T

G712V

1

15586G > T

A716S

1

15589G > T

D717Y

1

15593A > G

K718R

2

15594G > T

K718N

1

15596A > G

Y719C

2

15598G > T

V720F

1

15602G > A

R721H

1

15613C > T

H725Y

2

15619C > T

L727F

1

15627G > T

E729D

1

15636T > A

Y732*

1

15638G > A

R733K

1

15640A > T

N734Y

1

15641A > C

N734T

1

15647A > G

D736G

4

15652G > T

D738Y

2

15656C > T

T739I

1

15664G > A

V742M

1

15665T > C

V742A

1

15665T > G

V742G

1

15668A > G

N743S

1

15672G > T

E744D

8

15682T > A

Y748N

1

15683A > T

Y748F

1

15685T > A

L749M

1

15688C > T

R750C

1

15689G > A

R750H

1

15696T > G

H752Q

1