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Fig. 5 | Virology Journal

Fig. 5

From: The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice

Fig. 5

Both PRV-ΔgE/ΔgI/ΔTK and PRV-ΔgE/ΔgI/ΔTK-(CD2v) can activate the immune responses and cause the proliferation of immune cells leading to splenomegaly. a The spleen of 72 hpi mice inoculated with PRV-ΔgE/ΔgI/ΔTK and PRV-ΔgE/ΔgI/ΔTK-(CD2v) was swollen obviously. b Spleen weight statistics. c H & E staining showed that the spleen of PRV-ΔgE/ΔgI/ΔTK and PRV-ΔgE/ΔgI/ΔTK-(CD2v) infected groups had a large number of immune cell accumulation, as shown by the black arrow. Unpaired t-test was performed by GraphPad Prism 5.0, GraphPad Software (San Diego, CA, USA), ***p < 0.001 (n = 5/each group)

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