Table 2 Comparison of demographic, epidemiological and clinical variables between positive and negative HPV patients
From: Italian observational study on HPV infection, E6, and p16 expression in men with penile cancer
HPV negativity | HPV positivity | P value | |
|---|---|---|---|
Mean age (SD), years | 69.6 (10.6) | 64.1 (13.7) | 0.24 |
Age ≥ 55 years, n (%) | 21/23 (91.3) | 7/9 (77.8) | 0.56 |
Civil status, n (%) | |||
Married | 8/12 (66.7) | 5/5 (100.0) | 0.34 |
Single | 2/12 (16.7) | 0/5 (0.0) | |
Widower | 2/12 (16.7) | 0/5 (0.0) | |
Occupational status, n (%) | |||
Employed | 5/12 (41.7) | 2/6 (33.3) | 0.73 |
Retired | 7/12 (58.3) | 4/6 (66.7) | |
Familiarity for carcinoma, n (%) | 1/11 (9.1) | 0/4 (0.0) | 1.0 |
Suspected diagnosis of carcinoma, n (%) | 16/17 (94.1) | 7/8 (87.5) | 1.0 |
Cancer diagnosed before 2010, n (%) | 7/23 (30.4) | 3/9 (33.3) | 1.0 |
Anatomic site, n (%) | |||
Glans | 18/23 (78.3) | 6/9 (66.7) | 1.0 |
Penis | 5/23 (21.7) | 3/9 (33.3) | 1.0 |
Histopathological results, n (%) | |||
Squamous Cell Carcinoma | 23/23 (100.0) | 7/9 (77.8) | 0.07 |
Hyperplasia | 0/23 (0.0) | 1/9 (11.1) | |
Fibrosis | 0/23 (0.0) | 0/9 (0.0) | |
Well differentiated, n (%) | 15/23 (65.2) | 4/9 (44.4) | 0.43 |
Moderately differentiated, n (%) | 6/23 (26.1) | 2/9 (22.2) | 1.0 |
Poorly differentiated, n (%) | 2/23 (8.7) | 3/9 (33.3) | 0.12 |
Histopathological grading (AJCC), n (%) | |||
G1 | 15/23 (65.2) | 4/9 (44.4) | 0.25 |
G2 | 6/23 (26.1) | 2/9 (22.2) | |
G3 | 2/23 (8.7) | 3/9 (33.3) | |
Primary tumour (T) (AJCC), n (%) | |||
Tis | 2/23 (8.7) | 1/9 (11.1) | 0.83 |
T1 | 13/23 (56.5) | 5/9 (55.6) | |
T1a | 2/23 (8.7) | 0/9 (0.0) | |
T1b | 1/23 (4.4) | 0/9 (0.0) | |
T2 | 1/23 (4.4) | 0/9 (0.0) | |
T3 | 3/23 (13.0) | 1/9 (11.1) | |
NC | 1/23 (4.4) | 2/9 (22.2) | |
p-16 immunohistochemistry positivity, n (%) | 1/23 (4.4) | 6/9 (66.7) | 0.001 |
E6 gene positivity, n (%) | 0/0 (0.0) | 5/7 (71.4) | – |
Outcome, died | 11/23 (47.8) | 3/9 (33.3) | 0.69 |