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Fig. 2 | Virology Journal

Fig. 2

From: Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV

Fig. 2

Monovalent vaccination elicits cross-nAb to low sequence similarity isolates. a Neutralization of HCVpp pseudotyped with H77.20 (1a), UKNP1.4.1 (1a), 1bTO (1b), UKNP2.4.1 (2a), UKNP3.2.1 (3a), UKNP4.1.1 (4a), UKNP5.1.1 (5a), and UKNP6.1.1 (6a) at 1:100 serum dilution. Neutralization was normalized to the infectivity of uninhibited virus. Statistical analysis was done by unpaired t test followed by FDR (Q = 0.05) adjustment for multiple comparison (*FDR-adjusted P < 0.05). Only significant differences were highlighted. b The residual infectivity of variants treated with vaccine sera was plotted against immunogen-virus Hamming distance. Hamming distance was calculated as the number of differing residues in the 21 AA immunogen alignment. c Residual infectivity was mapped against a secondary structure factor (HELIXF2), calculated for each aligned HVR1 sequence using the program CRASP. Statistical analysis was done using linear regression, *P < 0.05

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