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Table 1 Antimicrobial activity of MMPphg on various Gram-negative or Gram-positive bacteria. The significant log reduction units observed (≥ 1 log kill) are marked in bold

From: MMPphg from the thermophilic Meiothermus bacteriophage MMP17 as a potential antimicrobial agent against both Gram-negative and Gram-positive bacteria

Strain Antibiotic resistance a Antimicrobial activity (Log10 reduction) b
Escherichia coli
 CMCC(B)44102 No 3.23 ± 0.15 (***)
Staphylococcus aureus
 ATCC6538 No 1.31 ± 0.03 (***)
 KMUST1606BL1486 Yes 1.04 ± 0.11 (***)
Salmonella ser. Enteritidis
 CMCC(B)50335 No 1.08 ± 0.03 (***)
Salmonella ser. Typhi
 CGMCC1.1190 No 0.92 ± 0.01
Salmonella ser. Paratyphi B
 CMCC(B)50094 No 3.42 ± 0.15 (***)
Shigella dysenteriae
 KMUSTDS8 Yes 0.96 ± 0.01
 KMUSTDS6 Yes 1.01 ± 0.01 (***)
Klebsiella pneumoniae
 13A14165 Yes 3.02 ± 0.01 (***)
 13A14918 Yes 1.47 ± 0.03 (***)
 13A15188 Yes 2.49 ± 0.07 (***)
 13A15382 Yes 1.59 ± 0.03 (***)
 1412SP0200 Yes 1.24 ± 0.02 (***)
 1412SP0057 Yes 2.26 ± 0.10 (***)
 13 V1837 Yes 0.97 ± 0.03
 14 V0622 Yes 1.09 ± 0.02 (***)
 1501SP0134 Yes 2.57 ± 0.07 (***)
  1. aDetailed antibiotic-resistant information for the relevant strains is shown in Additional file 4: Table S2; bValues represent mean ± standard deviation. For all tests, the antimicrobial activity was measured after incubating 106 CFU/mL of the bacterial cells with 6 μM MMPphg at 37 °C for 1 h, and six independent replicates were run in each reaction. ***, P < 0.001 for MMPphg-treated cells versus PBS-treated controls