Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12985-020-01395-x/MediaObjects/12985_2020_1395_Fig1_HTML.png)
Bioinformatic analyses of SARS-CoV-2 and other human coronaviruses. a Maximum likelihood phylogenetic tree of the whole genome sequences of SARS-CoV-2 Wuhan-Hu-1 (MN908947.3) and related coronaviruses including human coronavirus HCoV-229E (AF304460.1), HCoV-NL63 (AY567487.2), HCoV-OC43(AY585228.1), HCoV-HKU1(MH940245.1), and SARS-CoV (strain: Urbani, AY278741.1; strain: Tor2, AY274119.3), MERS-CoV (strain: HCoV-EMC, JX869059.2). b Heat map of RSCU values for the complete coding sequences of SARS-CoV-2 and other human coronaviruses. The heatmap analysis was performed using CIMminer. Each column represents a codon. Codons with higher RSCU values are highlighted with a red background. c The profiles of the relative synonymous codon usage for different genes of SARS-CoV-2 and other human coronaviruses. RSCU values were shown as the vertical bar graph. S:spike; E:envelop; M: membrane; N: nucleocapsid