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Table 2 Parameters of simulated scenarios

From: Disease burden of chronic hepatitis B and complications in China from 2006 to 2050: an individual-based modeling study

Scenarios

Assumption

2006–2017

2018–2020

2021–2030

2031–2050

Natural

Incidence

Historical data

851,659(2017 incidence)

851,659(2017 incidence)

85,159(2017 incidence)

Dx%

No diagnosis

No diagnosis

No diagnosis

No diagnosis

Tx%

No treatment

No treatment

No treatment

No treatment

Base-case

Incidence

Historical data

851,659(2017 incidence)

851,659(2017 incidence)

851,659(2017 incidence)

Dx%

18.70%

18.70%

18.70%

18.70%

Tx%

10.83%

10.83%

10.83%

10.83%

WHO target

Incidence

Historical data

555,858 in 2020 (70% of 2015)*

79,408 in 2030 (10% of 2015)*

79,408(2030 incidence)

Dx%

18.70%

30% in 2020*

90% in 2030*

90%(2030 rate)

Tx%

10.83%

10.83%

80% in 2030*

80%(2030 rate)

Ideal 1

(Dx% = 1; Tx% = 1)

Incidence

Historical data

555,858 in 2020 (70% of 2015)*

79,408 in 2030 (10% of 2015)*

79,408(2030 incidence)

Dx%

18.70%

100%

100%

100%

Tx%

10.83%

100%

100%

100%

Ideal 2

Incidence

Historical data

555,858 in 2020 (70% of 2015)*

79,408 in 2030 (10% of 2015)*

79,408(2030 incidence)

(Eligible% = 1)

Dx%

18.70%

30% in 2020*

90% in 2030*

90%(2030 rate)

Tx%

10.83%

10.83%

80% in 2030*

80%(2030 rate)

  1. Dx%: diagnosis rate
  2. Tx%: treatment rate (treatment/treatment eligible)
  3. Eligible%: treatment eligible proportion (patients indicated for treatment/all hepatitis and cirrhosis patients)
  4. *Dx% and Tx% in 2018–2019 and 2021–2029 were estimated through linear regression (Supplementary Table 6)