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Table 3 Drug resistance mutations (DRMs) found and implications on available drug regimen

From: Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana

Study ID Subtype DRM ARV
PR RT
1 CRF02_AG F77L ABC, AZT, D4T, DDI, TDF, 3TC, FTC
2 CRF02_AG L10F FPV/r, IDV/r, NFV, LPV/r,
3 CRF02_AG E138A ETR, RPV
4 B   K65R ABC, AZT, D4T, DDI, TDF
  1. Table 3 Indicates the PR and RT related DRMs found and their drug resistance implications on available antiretroviral drug regimen. No major PR-related DRM was observed in the samples whilst major RT-related DRMs in two (2) samples were found; E138A in one sample and another with K65R
  2. NB:[A Alanine, D Aspartate, E Glutamate, F Phenylalanine, L Leucine, V Valine, K Lysine, R Arginine, FPV/r Ritonavir-boosted fosamprenavir, IDV/r Ritonavir-boosted indinavir, NFV Nelfinavir, LPV/r Ritonavir-boosted lopinavir, ABC Abacavir, AZT Zidovudine, D4T Stavudine, DDI Didanosine, TDF Tenofovir, 3TC Lamivudine, FTC Emtricitabine, ETR Etravirine, RPV Rilpivirine, NVP Nevirapine, EFV Efavirenz]
  3. Key: CRF Circulating recombinant form
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