Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana

Table 3 Drug resistance mutations (DRMs) found and implications on available drug regimen

Study ID	Subtype	DRM		ARV
Study ID	Subtype	PR	RT	ARV
1	CRF02_AG	–	F77L	ABC, AZT, D4T, DDI, TDF, 3TC, FTC
2	CRF02_AG	L10F	–	FPV/r, IDV/r, NFV, LPV/r,
3	CRF02_AG	–	E138A	ETR, RPV
4	B		K65R	ABC, AZT, D4T, DDI, TDF

Table 3 Indicates the PR and RT related DRMs found and their drug resistance implications on available antiretroviral drug regimen. No major PR-related DRM was observed in the samples whilst major RT-related DRMs in two (2) samples were found; E138A in one sample and another with K65R
NB:[A Alanine, D Aspartate, E Glutamate, F Phenylalanine, L Leucine, V Valine, K Lysine, R Arginine, FPV/r Ritonavir-boosted fosamprenavir, IDV/r Ritonavir-boosted indinavir, NFV Nelfinavir, LPV/r Ritonavir-boosted lopinavir, ABC Abacavir, AZT Zidovudine, D4T Stavudine, DDI Didanosine, TDF Tenofovir, 3TC Lamivudine, FTC Emtricitabine, ETR Etravirine, RPV Rilpivirine, NVP Nevirapine, EFV Efavirenz]
Key: CRF Circulating recombinant form

ISSN: 1743-422X