Table 4 Summary of HIF1α inhibitors

HIF1α mRNA

EZN-2968

HIF1α

[117]

HIF1α Translation

Topotecan / AZN-2208

Topoisomerase 1

[6, 127]

PX-478

HIF1 / HIF2 Protein

[88]

Digoxin

HIF1α protein

[156]

Temisirolimus / Everolimus / MLN0128 / Metformin

mTOR

[73, 157]

Wortmannin

PI3K

[155]

HIF1α Degradation

17-AAG / 17-DMAG

HSP90

[110]

Romidepsin / Trichostatin

HDAC

[71, 81]

LW6

HDAC / VHL

[85]

HIF1α DNA Binding

DJ12

HRE

[79]

HIF1α transcriptional activity

Chetomin

CH1 domain pf p300

[83]