Table 1 Strategies of some viruses for inhibiting SG formation. Viruses have evolved the following strategies to regulate SGs and thus promote their survival
Virus | Viral protein | Strategies for resisting SG formation | Reference |
|---|---|---|---|
Rotavirus | Changes the cellular localization of TIA-1 and PABP | [5] | |
MNV | Recruits G3BP1 to the viral replication complex | [84] | |
ZIKV | Alters the cellular localization of HuR | [109] | |
EV71 | 2A | Cleaves eIF4GI | [110] |
EV71 | 3C | Cleaves G3BP1 | [111] |
PV | 3C | Cleaves G3BP1 | [112] |
FMDV | L | Cleaves G3BP1 and G3BP2 | [113] |
EMCV | 3C | Cleaves G3BP1 | [58] |
Picornavirus | L or 2A | Interferes with the eIF4GI-G3BP1 interaction | [114] |
HPIV3 | Hides viral RNA | [115] | |
HIV-1 | Inhibits PKR and eIF2α phosphorylation |