Fig. 1

Nucleotide sequence variations in the HPV E6-E7-L1 isolates in Korean women. ^*Previously reported: N, No ^†Grade of cervical lesions: ① Normal, ② ASCUS, ③ LSIL/CIN1, ④ HSIL/CIN2 and 3, ⑤ Cancer ^‡L1 secondary structure: H, helix; C, coil; S, strand Abbreviations: AA, Asian-Amerindian; E, European; ASCUS, Atypical squamous cells of undetermined significance; LSIL, Low-grade squamous intraepithelial lesion; HSIL, High-grade squamous intraepithelial lesion; CIN, Cervical intraepithelial neoplasia; na, not assessed; aa, amino acid. E6, E7 and L1 nucleotide positions at which variations were observed are written vertically across the top. Amino acid translations and immunodominant loop structures of L1 are shown at the bottom. The GenBank accession numbers of the newly discovered sequences are on the left. The phylogenetic groupings based on the analysis of E6-E7 are indicated. For each variant sequence, the positions that do not vary relative to the HPV reference are marked with a blank. The regions where sequencing failed are marked with an X. The cervical lesion grade for each variant is shown on the right