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Fig. 5 | Virology Journal

Fig. 5

From: Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment

Fig. 5

Histological and immunohistochemical variations following treatment of syngeneic TC-1 tumor model with oncolytic NDV. a At two weeks following final treatments, mice were sacrificed and sections of paraffin embedded or frozen tumor tissue from each group were stained with hematoxylin and eosin (H&E) for evaluation of tumor cells proliferation and signs of necrosis. Moreover, immunohistochemistry (IHC) staining was done for screening CD11b + and Gr-1+ markers. H&E, × 100 magnification, and IHC, × 40 magnification. Scale bars, 100 μm b The expression level of Gr-1+ in tumor sections of treatment groups. c The expression level of CD11b + in tumor sections of treatment groups. Immunohistochemical analysis was performed by ImageJ software. Data are expressed as means ± SEM (b and c). n = 3 mice per group (b and c). * P < 0.05; ** P < 0.01; *** P < 0.001

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