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Fig. 3 | Virology Journal

Fig. 3

From: Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment

Fig. 3

Lymphocyte proliferation assay and cytotoxic T lymphocyte response following treatment with MSCs loaded with oncolytic NDV. a The results indicate that MSC/NDV and NDV groups stimulate significant differences when compared with MSC/iNDV, iNDV (P < 0.001), PBS and MSC control groups (P < 0.001). Also, the stimulation index was significant in MSC/iNDV and iNDV treated groups compared to MSC and PBS control groups (P < 0.05). b Results reveal that treatment with MSC/NDV and NDV groups can significantly increase CTL responses compared with control groups (MSC and PBS groups) (P < 0.001). Also, cytolytic analysis of CTL lymphocytes demonstrated a greatly increased CD8+ activity in the group of mice treated with MSC/NDV compared with the NDV group (p < 0.05). The results are representative of three independent experiments. * P < 0.05; ** P < 0.01; *** P < 0.001

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Virology Journal

ISSN: 1743-422X