Fig. 1

The MCPyV NCCR region and the different variants. The top panel of the figure shows the consensus nucleotide sequence based on variant R17b (GenBank accession number NC_010277), with the first nucleotide in the NCCR numbered 1 and the last numbered 464. The putative LT binding sequences (GRGGC) are shown in boxes. The bottom part shows a schematic presentation of the NCCR, with the thick vertical lines representing putative LT binding motifs [37]. The early region is indicated on the left and the late region on the right. The different groups of NCCR variants and their major mutations are indicated. The larger insertions (ins) and deletions (Δ) are given, whereas point mutations are not shown