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Table 2 The subtype distribution of the ART failures patients from 2012 to 2017. and the different drug resistance classes (single/double/ Triple drug resistance) in these patients

From: Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China

Year

2012

2013

2014

2015

2016

2017

total

ART Failure

130

303

585

675

703

536

2932

Obtained sequence

112

239

508

511

528

397

2295

Subtype

AE

75 (66.96%)

163 (68.20%)

355 (69.88%)

365 (71.43%)

294 (55.68%)

220 (55.42%)

1472 (64.14%)

BC

11 (9.82%)

26 (10.88%)

80 (15.75%)

106 (20.74%)

115 (21.78%)

73 (18.39%)

411 (17.91%)

B

21 (18.75)

37 (15.48%)

52 (10.24%)

30 (5.87%)

66 (12.50%)

58 (14.61%)

264 (11.50%)

C

4 (3.57)

13 (5.44%)

20 (3.94%)

9 (1.76%)

23 (4.53%)

12 (3.02%)

81 (3.53%)

Other

1 (0.89%)

0

1 (0.20%)

1 (0.20%)

30 (5.68%)

34 (8.56%)

67 (2.92%)

DRMs

42

84

201

215

209

163

 

Only PI

0

0

1

3

4

2

10

Only NRTI

1

1

13

6

21

7

49

Only NNRTI

6

23

57

56

50

29

221

PI and NRTI

0

0

0

1

1

2

4

PI and NNRTI

0

0

0

0

3

1

4

NRTI and NNRTI

35

60

129

144

121

94

583

PI and NRTI and NNRTI

0

0

1

5

9

28

43

  1. Note: ART Antiretroviral therapy
  2. DRMs Drug resistance mutations
  3. PI Protease inhibitor
  4. NRTI Nucleoside reverse transcriptase inhibitors
  5. NNRTI Non-nucleoside reverse transcriptase inhibitors