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Table 5 Relation between demographic and clinical characteristics of patients with mono-viral infection and viral co-infection

From: Co-infections of human herpesviruses (CMV, HHV-6, HHV-7 and EBV) in non-transplant acute leukemia patients undergoing chemotherapy

VariablesActive viral infection
(N = 84)
No. (%)
Active mono-viral infection
(N = 61)
No. (%)
Active viral co-infection
(N = 23)
No. (%)
P
Sex
 Male54 (64.3)34 (55.7)20 (86.9)0.007
 Female30 (35.7)27 (44.3)3 (13) 
Age (years)
  < 1649(58.3)37 (60.7)12 (52.2)0.482
  ≥ 1635 (41.7)24 (39.3)11 (47.8) 
Type of leukemia
 AML36 (42.9)25 (41)11 (47.8)0.572
 ALL48 (57.1)36 (59)12 (52.2) 
Status of disease
 Newly diagnosed9 (10.7)7 (11.5)2 (8.7)0.443
 Remission54 (64.3)41 (67.2)13 (56.5) 
 Refractory or relapse21 (25)13 (21.3)8 (34.8) 
Chemotherapy received
 Before chemotherapy9 (10.7)7 (11.5)2 (8.7)0.607
 Post-induction21 (25)13 (21.3)8 (34.8) 
 Post-remission28 (33.3)22 (36)6 (26.1) 
 Post-salvage26 (31)19 (31.1)7 (30.4) 
Clinical outcome
 Alive72 (85.7)55 (90.2)17 (74)0.058
 Dead12 (14.3)6 (9.8)6 (26) 
Fever56 (66.6)41 (67.2)15 (65.2)0.863
Severe neutropenia48 (57.2)32 (52.5)16 (69.5)0.158
Prolonged neutropenia38 (45.3)27 (44.3)11 (47.8)0.209
Severe lymphopenia45 (53.5)25 (41)20 (87)< 0.001
Anemia28 (33.3)20 (32.8)8 (43.8)1.000
Thrombocytopenia29 (34.5)21 (34.4)8 (43.8))0.986
Skin rash17 (20.2)8 (13.1)9 (39.1)0.04
Mucositis5 (6)3 (5)2 (8.7)0.514
Pneumonia17 (20)8 (13.1)9 (39)0.008
Gastroenteritis10 (11.9)7 (11.5)3 (13)0.843
Hepatitis12 (14.3)7 (11.5)5 (21.7)0.231
Conjunctivitis2 (2.4)0 (0)2 (8.7)
CNS disorders7 (8.3)3 (5)4 (17.4)0.065
Other infection
BSI16 (19)6 (9.8)10 (43.5)< 0.001
IFI14 (16.6)7 (11.5)7 (30.4)0.038
  1. Viral infections were divided into two groups based on the number of viruses detected: active mono-viral infections and co-infections
  2. Severe neutropenia [ANC < 500/μL]; Prolonged neutropenia [if it persisted over 7 days]; Severe lymphopenia [ALC < 500/μL]; Anemia [hemoglobin < 11 g/L], Thrombocytopenia [platelet count < 100 10 3/ μL]; CNS disorders Central Nervous System disorders, BSI Blood Stream Infection, IFI Invasive Fungal Infection
  3. Statistically significant p are bolded