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Table 5 Relation between demographic and clinical characteristics of patients with mono-viral infection and viral co-infection

From: Co-infections of human herpesviruses (CMV, HHV-6, HHV-7 and EBV) in non-transplant acute leukemia patients undergoing chemotherapy

Variables Active viral infection
(N = 84)
No. (%)
Active mono-viral infection
(N = 61)
No. (%)
Active viral co-infection
(N = 23)
No. (%)
P
Sex
 Male 54 (64.3) 34 (55.7) 20 (86.9) 0.007
 Female 30 (35.7) 27 (44.3) 3 (13)  
Age (years)
  < 16 49(58.3) 37 (60.7) 12 (52.2) 0.482
  ≥ 16 35 (41.7) 24 (39.3) 11 (47.8)  
Type of leukemia
 AML 36 (42.9) 25 (41) 11 (47.8) 0.572
 ALL 48 (57.1) 36 (59) 12 (52.2)  
Status of disease
 Newly diagnosed 9 (10.7) 7 (11.5) 2 (8.7) 0.443
 Remission 54 (64.3) 41 (67.2) 13 (56.5)  
 Refractory or relapse 21 (25) 13 (21.3) 8 (34.8)  
Chemotherapy received
 Before chemotherapy 9 (10.7) 7 (11.5) 2 (8.7) 0.607
 Post-induction 21 (25) 13 (21.3) 8 (34.8)  
 Post-remission 28 (33.3) 22 (36) 6 (26.1)  
 Post-salvage 26 (31) 19 (31.1) 7 (30.4)  
Clinical outcome
 Alive 72 (85.7) 55 (90.2) 17 (74) 0.058
 Dead 12 (14.3) 6 (9.8) 6 (26)  
Fever 56 (66.6) 41 (67.2) 15 (65.2) 0.863
Severe neutropenia 48 (57.2) 32 (52.5) 16 (69.5) 0.158
Prolonged neutropenia 38 (45.3) 27 (44.3) 11 (47.8) 0.209
Severe lymphopenia 45 (53.5) 25 (41) 20 (87) < 0.001
Anemia 28 (33.3) 20 (32.8) 8 (43.8) 1.000
Thrombocytopenia 29 (34.5) 21 (34.4) 8 (43.8)) 0.986
Skin rash 17 (20.2) 8 (13.1) 9 (39.1) 0.04
Mucositis 5 (6) 3 (5) 2 (8.7) 0.514
Pneumonia 17 (20) 8 (13.1) 9 (39) 0.008
Gastroenteritis 10 (11.9) 7 (11.5) 3 (13) 0.843
Hepatitis 12 (14.3) 7 (11.5) 5 (21.7) 0.231
Conjunctivitis 2 (2.4) 0 (0) 2 (8.7)
CNS disorders 7 (8.3) 3 (5) 4 (17.4) 0.065
Other infection
BSI 16 (19) 6 (9.8) 10 (43.5) < 0.001
IFI 14 (16.6) 7 (11.5) 7 (30.4) 0.038
  1. Viral infections were divided into two groups based on the number of viruses detected: active mono-viral infections and co-infections
  2. Severe neutropenia [ANC < 500/μL]; Prolonged neutropenia [if it persisted over 7 days]; Severe lymphopenia [ALC < 500/μL]; Anemia [hemoglobin < 11 g/L], Thrombocytopenia [platelet count < 100 10 3/ μL]; CNS disorders Central Nervous System disorders, BSI Blood Stream Infection, IFI Invasive Fungal Infection
  3. Statistically significant p are bolded