Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan’s unique ecosystems against influenza viruses and paramyxoviruses

Table 2 Specific antiviral action (SI-index) of preparations obtained from extremophilic actinomycetes against ortho- and paramyxoviruses. SI was determined by the ratio of average toxic substance concentration (TC₅₀) to average effective virus-inhibiting concentration (EC₅₀). SI-index greater than or equal to 10 marked good antiviral action of actinomycetes extracts that specifically killed the virus. The actinomycetes extracts K-340-2S, K-362-2 N, K-362-1S, K-362-2S demonstrated high virus-inhibition activity against all investigated strains of influenza virus. Only the extracts K-192-1S and K-192-2S showed good SI against PMV-1/Beadette virus strain. For strain K-525 extract of biomass grown in saline conditions, K-525-2S, had higher SI indexes against tested viral strains than extracts from culture liquid or biomass extract grown in neutral condition. Overall, biomass extracts grown in saline conditions had better specific antiviral action than extracts grown from culture liquid in neutral conditions

Viruses	Influenza virus H3N2	Influenza virus H1N1	Influenza virus H5N3	Influenza virus H7N1	PMV-1/Beadette	Sendai. strain 960
Preparations	SI	SI	SI	SI	SI	SI
K-192-1S	10	10	2	10.5	10	11.76
K-192-2S	28.6	40	40	5	10	9.3
K-340-1 N	2	2	2	2	2	11.1
K-340-2S	28.6	28.57	13.3	40	2	1
K-362-2 N	12.5	40	10	40	2	5.4
K-362-1S	40	40	40	28.57	8.7	8.7
K-362-2S	40	40	40	40	2	11.76
K-522-CBN	2	2	2	2	2	13.3
K-522-1S	2	2	2	2	2	10
K-522-2S	10	5.88	2	11.76	2	2
K-525-CBN	2	2	2	2	2	10
K-525-1 N	2	2	2	10	2	2
K-525-2 N	2	25	2	2	2	11.1
K-525-1S	2	2	2	2	2	10
K-525-2S	2	40	28.57	33.3	2	14.29

ISSN: 1743-422X