Fig. 2

ROC-curves for women with hrHPV transient infections and women with hrHPV persistent infections with CIN2+ lesions. 50% of the samples were used for 5-fold cross-validation training in general linear modeling, and the models where then applied to the remaining 50% of the samples. 95% confidence intervals for sensitivity and specificity are shown as blue field (sensitivity) and green filed (specificity). Performance of trained model with validation set: A. HPV16 copy number, B. HPV16 titer, C. total hrHPV copy number, D. total hrHPV titer. The AUC with 95% confidence interval is given in each panel. Best point is indicated with black point and point estimates of performance. The best point is defined as the point on the ROC with closest to perfect classification, sensitivity and specificity 1.0