Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

Larguet, Fadila; Caté, Clément; Barbeau, Benoit; Rassart, Eric; Edouard, Elsy

doi:10.1186/s12985-019-1249-y

Virology Journal

Table 1 HIV-1 integrase interacting proteins identified by mass spectrometry

From: Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

Identified protein	Gene name	Accession no	MW (KDa)	Total score	peptide no	% coverage	Main biological function
Band 1
RNA helicase II/Gu protein	DDX21	gi\|11,890,755	80.210	658	21	27	rRNA processing
Transducin beta-like 3	TBL3	gi\|16,307,379	90.347	605	16	25	Signalling, rRNA processing
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	DDX1	gi\|31,565,475	83.349	462	12	20	Transcription, mRNA processing
ATP-dependent DNA helicase II (Ku80)	XRCC5	gi\|10,863,945	83.222	461	11	18	DNA repair, Transcription
Transcription factor NF-AT 90 K chain – human	ILF3	gi\|1,082,856	73.977	302	9	17	Transcription
Band 2
RNA helicase II/Gu protein	DDX21	gi\|11,890,755	80.210	423	13	nd	rRNA processing
HnRNP R protein	HNRNPR	gi\|12,655,185	71.456	413	9	nd	mRNA splicing, processing
Structure specific recognition protein 1	SSRP1	gi\|4,507,241	81.367	298	5	10	DNA repair, Transcription
Metastasis-associated protein	MTA1	gi\|2,498,589	81.422	163	4	nd	Signal transduction
Band 3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	DDX5	gi\|4,758,138	69.618	999	43	36	mRNA processing
Heat shock protein (HSP70–1/2)	HSPA1A	gi\|386,785	70.110	571	12	20	Stress response
Fused in sarcoma	FUS	gi\|48,145,611	53.622	525	22	23	Nuclear mRNA splicing
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	DDX17	gi\|47,678,395	73.138	464	18	16	RNA processing
HNop56	NOP56	gi\|2,230,878	67.206	451	10	23	rRNA processing
Band 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	DDX5	gi\|4,758,138	69.618	758	21	nd	mRNA processing
Paraspeckle component 1	PSPC1	gi\|57,209,129	58.820	719	25	28	Transcription regulation
HnRNP R protein	HNRNPR	gi\|12,655,185	71.456	423	19	16	mRNA splicing, processing
HnRNP L	HNRNPL	gi\|11,527,777	64.617	404	10	23	Nuclear mRNA splicing
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	DDX17	gi\|47,678,395	73.138	310	9	nd	RNA processing
Band 5
Unnamed protein product (homologue to hnRNP L)	HNRNPL	gi\|32,356	60.719	812	32	45	Nuclear mRNA splicing
Poly(ADP-ribose) polymerase	PARP1	gi\|190,167	113.810	327	7	8	DNA repair, Transcription
Histone deacetylase 1	HDAC1	gi\|13,128,860	55.638	319	9	22	Transcription
Telomeric repeat binding factor 2	TERF2	gi\|5,032,169	55.688	302	6	20	Cell cycle
Transcription factor LSF	TFCP2	gi\|476,099	57.733	244	5	nd	Transcription
Band 6
NF45	ILF2	gi\|532,313	44.898	469	11	18	Transcription
Flap structure-specific endonuclease 1	FEN1	gi\|54,695,918	42.908	453	13	31	DNA repair
Vaccinia related kinase 1	VRK1	gi\|4,507,903	45.790	439	12	nd	Cell cycle
DEAD (Asp-Glu-Ala-Asp) box polypeptide 48	EIF4A3	gi\|13,177,790	47.126	422	10	27	mRNA metabolism, rRNA processing
HnRNP D	HNRNPD	gi\|870,743	30.523	394	12	29	Transcription
Band 7
Apurinic endonuclease	APEX1	gi\|178,743	35.959	488	14	40	DNA repair, Transcription
Protein phosphatase 1, catalytic subunit, alpha isoform 1	PPP1CA	gi\|4,506,003	38.229	465	9	nd	Cell cycle, Carbohydrate metabolism
protein phosphatase-1 gamma 1	PPP1CC	gi\|484,316	37.271	456	9	29	Cell cycle, Carbohydrate metabolism
ELAV-like 1	ELAVL1	gi\|38,201,714	36.240	393	10	30	mRNA stabilization
B23 nucleophosmin (280 AA)	NPM1	gi\|825,671	31.090	332	13	21	Ribosome assembly, signal transduction, intracellular protein transport
Band 8
Ribosomal protein L7a	RPL7A	gi\|49,522,232	30.148	421	8	nd	60S ribosomal constituent
N-methylpurine-DNA glycosylase; MPG	MPG	gi\|233,968	30.005	392	9	33	DNA repair
Histone H1	HIST1H1D	gi\|22,770,675	22.336	323	6	nd	Nucleosome structure
Homolog of Yeast RRP4	EXOSC2	gi\|12,653,909	32.996	312	6	nd	rRNA processing
Ribosomal protein S2	RPS2	gi\|23,491,733	25.874	227	5	19	40S ribosomal constituent
Band 9
High-mobility group box 2	HMGB2	gi\|54,696,428	24.061	389	20	44	DNA repair and recombination
Ribosomal protein L14	RPL14	gi\|1,620,022	23.902	252	6	25	60S ribosomal constituent
Ribosomal protein L13	RPL13	gi\|15,431,297	24.304	225	5	27	60S ribosomal constituent
High mobility group protein B1	HMGB1	gi\|48,145,843	25.035	214	13	nd	DNA repair and recombination, transcription.
Ras-related nuclear protein	RAN	gi\|48,734,884	24.609	176	5	22	Cell cycle, protein transport
Band 10
HMGB3 protein	HMGB3	gi\|47,124,341	23.137	555	35	48	DNA recombination
Cleavage and polyadenylation specific factor 5	NUDT21	gi\|12,655,103	26.268	466	13	30	mRNA processing
Splicing factor, arginine/serine-rich 9	SRSF9	gi\|4,506,903	25.640	386	13	nd	mRNA splicing, processing
HnRNP A1 (Helix-destabilizing protein)	HNRNPA1	gi\|47,939,618	34.273	352	20	nd	mRNA splicing, processing and transport
Protein C2f	EMG1	gi\|2,276,396	26.474	236	4	nd	Ribosome biogenesis
Band 11
RNA polymerase II subunit	POLR2H	gi\|1,017,823	17.203	198	7	27	Transcription
Ribosomal protein S19	RPS19	gi\|12,652,563	16.051	188	4	nd	40S ribosomal constituent
Histone H1b	HIST1H1B	gi\|356,168	21.721	158	3	nd	Nucleosome assembly
HIST1H2BN protein	HIST1H2BN	gi\|68,532,407	13.928	156	9	26	Nucleosome assembly
Band 12
Histone H1	HIST1H1D	gi\|22,770,675	22.336	323	6	nd	Nucleosome structure
HIST1H4I protein	HIST1H4I	gi\|45,767,731	11.332	249	8	40	Nucleosome assembly
Histone H4	HIST4H4	gi\|223,582	11.230	235	8	39	Nucleosome
HIST1H2BN protein	HIST1H2BN	gi\|68,532,407	13.928	98	4	nd	Nucleosome

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ISSN: 1743-422X

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