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Table 3 Amino acid differences between the wild-type strain G1 and the mouse-adapted strain G1-MA

From: Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice

ProteinsAA siteG1G1-MAAvian H9N2Human H9N2pH1N1Human H3N2
PB2590aSRG (97.5%)S (100%)S (85%)T (47%)
S (45%)
G (8%)
G(15%)
S (2.5%)
PA349cEKE (100%)E (100%)E (100%)E (100%)
486IMI (100%)I (100%)I (100%)I (100%)
HA204 (196)b cIMT (95%)T(60%)//
K (4.2%)I (40%)
A (0.6%)
I (0.2%)
206 (198)NTT (95%)T (60%)//
A (4.2%)
N (0.8%)
N (40%)
271 (263)GEE (99%)E (60%)//
G (0.5%)
V (0.5%)G (40%)
M1198QHQ (100%)Q (100%)Q (99%)Q (100%)
H (1%)
239ATA (100%)A (100%)A (100%)T (97%)d
A (2%)
V (1%)
M291CFF (99.8%)F (100%)F (51%)F (100%)
T (47%)
V (1%)
C (0.2%)L (1%)
93INN (99.5%)N (100%)N (89%)S (99%)
I (0.1%)
K (0.1%)
S (0.1%)
T (0.1%)S (9%)
D (1%)N (1%)
T (1%)
  1. aH9 numbering
  2. bH3 numbering is in parentheses
  3. cThe substitutions also occurred in mice-adapted influenza viruses in the previous studies
  4. dThe substitution which presents more frequently in human influenza viruses than H9N2 AIVs was shown by bold and underline formats