Combining HPV DNA load with p16/Ki-67 staining to detect cervical precancerous lesions and predict the progression of CIN1–2 lesions

Table 1 Distribution of HPV genotypes according to histopathological diagnosis

Type	Cervicitis	CIN1	CIN2	CIN3	cancer	Total	χ² value	P value
No HPV	35	27	12	2	3	79	/	/
HPV-16	14	17	24	61	25	141	76.408^**	< 0.001
HPV-18	9	1	3	1	2	16	6.535	0.258
HPV-31	3	5	2	6	0	16	22.199^**	< 0.001
HPV-33	4	2	7	7	1	21	26.592^**	< 0.001
HPV-35	5	1	4	2	1	13	8.849	0.115
HPV-39	6	4	1	1	1	13	1.792	0.877
HPV-45	1	0	1	1	0	3	9.314	0.097
HPV-51	5	2	5	4	0	16	15.747^**	0.008
HPV-52	15	17	12	10	2	56	12.243^*	0.032
HPV-56	4	4	1	1	0	10	2.136	0.83
HPV-58	9	15	17	19	1	61	32.6^**	< 0.001
HPV-59	2	1	2	3	0	8	17.891^**	0.003
HPV-68	1	4	3	2	1	11	9.782	0.082
Total	84	77	68	89	32	350	32.329^**	< 0.001

ISSN: 1743-422X