Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study

Table 1 Patient characteristics at inclusion

Number of patients	25
Gender (male/female)	15/10
Premature birth^a n (%)	5 (20%)
Season at birth^b
Spring	6 (24%)
Summer	6 (24%)
Fall	5 (20%)
Winter	8 (32%)
Maternal smoking during pregnancy	4 (16%)
Maternal atopy	6 (24%)
Parental smoking	15 (60%)
Siblings
0	12 (48%)
1	8 (32%)
≥2	5 (20%)
Daycare attendance^c	Family only: 13 (52%)
	Small group: 8 (32%)
	Collective: 4 (16%)
Demographics at inclusion
CFTR genotype with
No CFTR function	21 (84%)
Residual CFTR function	5 (16%)
Unknown consequences	0 (0%)
Age at inclusion (months)	9.4 ± 6.7
Range	2–22.9
Anthropometrics (Z-scores)
Weight	−1.3 ± 1.4
Height	−1.1 ± 1.5
Vaccination coverage rates
DTPa-IPV/Hib^d	25 (100%)
Influenza	22 (88%)
RSV prophylaxis (palivizumab)	0 (0%)
Bacteria recovered at inclusion
Oropharyngeal flora	15 (60%)
Staphylococcus aureus	8 (32%)
Pseudomonas aeruginosa	1 (4%)
Haemophilus influenzae	1 (4%)
Virus recovered at inclusion
None	10 (40%)
RV/EV	7 (28%)
Bocavirus	4 (16%)
Influenzae	2 (8%)
Metapneumovirus	1 (4%)
Cytomegalovirus^e	1 (4%)
RSV	0 (0%)

Results are presented as mean ± SD or n (%)
^aBirth before 37 weeks of gestational age
^bWinter: 22/12 to 19/03, spring: 20/03 to 20/06, summer: 21/06 to 21/09; fall: 22/09 to 21/12
^cSmall group means fewer than four children, collective daycare means more than or equal to four children
^dDTPa- IPV/Hib vaccine: diphtheria-tetanus, acellular pertussis, inactivated poliomyelitis, adsorbed conjugated Haemophilus influenzae type b vaccine
^eCytomegalovirus was not part of the viral panel. It was identified from a respiratory sample by viral culture

ISSN: 1743-422X