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Table 1 Antiviral activity of rosmarinic acid against EV71 infection

From: Evaluation of the virucidal effects of rosmarinic acid against enterovirus 71 infection via in vitro and in vivo study

MOI

EC50 (μM)

EC70 (μM)

EC90 (μM)

TI

0.1

2.19 ± 0.11

3.42 ± 0.07

4.16 ± 0.15

672.15

0.5

3.76 ± 0.24

5.23 ± 0.11

6.03 ± 0.14

393.33

1.0

4.33 ± 0.18

5.69 ± 0.22

6.50 ± 0.27

340.39

  1. EC50, EC75, and EC90 represent the concentrations that inhibit EV71-induced cytotoxicity by 50, 75, and 90%, respectively. RD cell cytotoxicity was determined by the MTT assay. Data are shown as means ± SD. Therapeutic index (TI) = CC50/EC50
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Virology Journal

ISSN: 1743-422X