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Table 1 Antiviral activity of rosmarinic acid against EV71 infection

From: Evaluation of the virucidal effects of rosmarinic acid against enterovirus 71 infection via in vitro and in vivo study

MOI EC50 (μM) EC70 (μM) EC90 (μM) TI
0.1 2.19 ± 0.11 3.42 ± 0.07 4.16 ± 0.15 672.15
0.5 3.76 ± 0.24 5.23 ± 0.11 6.03 ± 0.14 393.33
1.0 4.33 ± 0.18 5.69 ± 0.22 6.50 ± 0.27 340.39
  1. EC50, EC75, and EC90 represent the concentrations that inhibit EV71-induced cytotoxicity by 50, 75, and 90%, respectively. RD cell cytotoxicity was determined by the MTT assay. Data are shown as means ± SD. Therapeutic index (TI) = CC50/EC50