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Table 8 Genotype and allele frequencies of IL-β, IL17, IL10 and IL28 in influenza (A & B) and ILI groups

From: Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

Gene and genotype Flu A & B (%) ILI (%) Crude p value OR (95% CI) Adjusted p value
IL-1β; rs16944
 AA 7(22.6) 24(77.4)    
 GA 71(51.4) 67(48.6) .007*   
 GG 2(33.3) 4(66.7)    .027*
 GG vs. GA/AA 2(33.3) 78(46.2) 4(66.7) 91(53.8) .689 .547 (.096–3.127)  
 AA vs. GG/GA 7(22.6) 73(50.7) 24 (77.4) 71(49.3) .004* .235 (.091–.610)  
 A 85 115 .163 1.353 (.884–2.070)  
 G 75 75    
IL-17; rs2275913
 AA 6(40) 9(60)    
 AG 26(32.5) 54(67.5) .006*   .019*
 GG 44(57.9) 32(42.1)    
 GG vs. GA/AA 44(57.9) 32(33.7) 32(42.1) 63(66.3) .002* 2.589 (1.3714.889)  
 AA vs. AG/GG 6(40) 70(44.9) 9(60) 86(55.1) .717 .810 (.266–2.467)  
 A 38 72 .011* 1.831 (1.144–2.928)  
 G 114 118    
IL-10; rs1800872
 GG 4(50) 4(50) .760   
 TG 72(48.3) 77(51.7)    
 TT 4(36.4) 7(63.6)    .510
 TT vs. GG/TG 4(36.4) 76(48.4) 7(63.6) 81(51.6) .439 .619 (.170–2.256)  
 GG vs. TG/TT 4(50) 76(47.5) 4(50) 84(52.5) 1.000 .731 (.168–3.178)  
 G 80 85 .755 .934 (.609–1.433)  
 T 80 91    
IL-28; rs8099917
 GG 2(33.3) 4(66.7)    
 GT 42(46.7) 48(53.3) .889  
 TT 36(45.6) 43(54.4)    .784
 TT vs. GG/GT 36(45.6) 44(45.8) 43(54.4) 52(54.2) .972 .882 (.474–1.641)  
 GG vs. GT/TT 2(33.3) 78(46.2) 4(66.7) 91(53.8) .68 .669 (.116–3.841  
 G 46 56 .882 1.036 (.652–1.646)  
 T 114 134   
  1. OR Odds ratio, CI Confidence interval (calculated by logistic regression model)
  2. p value is significant