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Fig. 4 | Virology Journal

Fig. 4

From: The tree shrew is a promising model for the study of influenza B virus infection

Fig. 4

Inoculation of tree shrews with influenza B viruses causes inflammation in tissues of the respiratory tract. mRNA expression of IL-6 (a), IL-8 (b), IL-10 (c), IP-10 (d), TNF-α (e) and TGF-β (f) mRNA were increased at 2, 4 and 6 days post inoculation (DPI) in tissues of the respiratory tracts of tree shrews inoculated with influenza B virus. Statistically significant differences in fold expression levels of IL-6 (a) and IP-10 (d) were observed between tree shrews inoculated with the Yamagata or Victoria lineage virus. mRNA expression was detected via real-time PCR (SYBR Green) using GAPDH expression as a control. Fold changes are in comparison to uninoculated animals. Tree shrews were inoculated with either Yamagata strain B/Guangzhou/12/2016 (Y12) or Victoria strain B/Guangzhou/0215/2012 (V0215). **p < 0.01, *p < 0.05

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