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Table 3 Insertion and potential direct-acting antivirals resistance-associated substitutions of DE/−17–0414

From: Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

Genomic regions

Amino acid position

Reference amino acid

DE/−17–0414

Susceptibility to DAA according to Geno2Pheno[HCV] (Kalaghatgi et al., 2016)

E2

1a-1c

–

QSR

NAa

NS3

36

V

L

Substitution on scored position to Asunaprevir, Grazoprevir, Ledipasvir, Paritaprevir; Reduced susceptibility to Simeprevir, Telaprevir, Voxilaprevir; Resistant to Boceprevir

NS3

170

I

V

Substitution on scored position to Voxilaprevir

NS5A

28

L

M

Substitution on scored position to Ombitasvir

NS5A

31

L

M

Substitution on scored position to Velpatasvir

NS5A

93

Y

H

Substitution on scored position to Pibrentasvir; Resistant to Daclatasvir, Elbasvir, Ledipasvir, Ombitasvir, Velpatasvir

  1. aNA for not available
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Virology Journal

ISSN: 1743-422X