Fig. 6

Inhibition of the JAK/STAT pathway did not appear to affect virus output from infected bat cells. Cells were treated with 5 μM pyridone 6 (JAK inhibitor), for 20 h prior to infection with human USSR virus at 0.5 MOI. There was no notable difference in virus output between treated TB1-Lu, E. helvum and C. perspic cells, and their untreated counterparts. Pyridone 6 treated MDCK cells, however, showed a 2-fold increase in virus output. Results shown are representative of three experimental repeats