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Table 1 Monoclonal antibody characterization

From: Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope

mAb/ polyclonal sera M/H/C Binding Neutralization (W/M/S) Binding region Binding DENV serotypes Ref
  DV1 DV2 DV3 DV4 ZIKV  
4G2 M F-CR W DII FL ++ ++ +++ +++ +++ [26]
1F4 H DV1 DV1:S DI/DII hinge Q +++ [7]
12C1.5 M D-CR DV:S DIII ++ ++ +++ ++ [27]
1C19 H D-CR DV:M DII FL/BC ++ ++ ++ + ++ [28]
2D22 H DV2 DV2:S ZIKV:W DII/DIII Q ++ [5, 29]
5J7 H DV3 DV3:S DI/DII Q +++ [23]
5H2 C DV4 DV4:S DI Q + [24]
1 M7 H F-CR M DII FL +++ ++ +++ +++ +++ [30]
A11 (EDE2) H F-CR DV:S ZIKV:W DI/DII/DIII Q +++ +++ +++ +++ + [31]
B7 (EDE2) H F-CR DV:S ZIKV:W DI/DII/DIII Q +++ +++ +++ +++ + [31]
C8 (EDE1) H F-CR DV:S ZIKV:S DII/DIII Q +++ +++ +++ +++ ++ [31]
C10 (EDE1) H F-CR DV:S ZIKV:S DII/DIII Q +++ +++ +++ +++ ++ [31]
3H5 M DV2 DV2:S DIII LR +++ [32]
8A1 M DV3 DV3:S DIII +++ [33]
DV4 126 H DV4 DV4:S DI/DII hinge Q +++ [8]
DV4 131 H DV4 DV4:S DI/DII hinge Q +++ [8]
DV4 141 H DV4 None DIII +++ [8]
DT000 H D-CR DV:S ZIKV:W   +++ +++ +++ ++ [21]
  1. Dengue specific monoclonal antibodies. A panel of well-defined mouse, human or chimpanzee (M/H/C) derived Mabs were used to characterize sRecE epitopes. Flavivirus cross reactive (F-CR), dengue cross reactive (D-CR), weakly, moderately or strong (W/M/S) neutralizing, E-domain I, II, III (DI, DII, DIII), fusion loop (FL), BC-loop (BC), lateral ridge (LR), quaternary (Q)