Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope

Table 1 Monoclonal antibody characterization

mAb/ polyclonal sera	M/H/C	Binding	Neutralization (W/M/S)	Binding region	Binding DENV serotypes					Ref
					DV1	DV2	DV3	DV4	ZIKV
4G2	M	F-CR	W	DII FL	++	++	+++	+++	+++	[26]
1F4	H	DV1	DV1:S	DI/DII hinge Q	+++	–	–	–	–	[7]
12C1.5	M	D-CR	DV:S	DIII	++	++	+++	++	–	[27]
1C19	H	D-CR	DV:M	DII FL/BC	++	++	++	+	++	[28]
2D22	H	DV2	DV2:S ZIKV:W	DII/DIII Q	–	++	–	–	–	[5, 29]
5J7	H	DV3	DV3:S	DI/DII Q	–	–	+++	–	–	[23]
5H2	C	DV4	DV4:S	DI Q	–	–	–	+	–	[24]
1 M7	H	F-CR	M	DII FL	+++	++	+++	+++	+++	[30]
A11 (EDE2)	H	F-CR	DV:S ZIKV:W	DI/DII/DIII Q	+++	+++	+++	+++	+	[31]
B7 (EDE2)	H	F-CR	DV:S ZIKV:W	DI/DII/DIII Q	+++	+++	+++	+++	+	[31]
C8 (EDE1)	H	F-CR	DV:S ZIKV:S	DII/DIII Q	+++	+++	+++	+++	++	[31]
C10 (EDE1)	H	F-CR	DV:S ZIKV:S	DII/DIII Q	+++	+++	+++	+++	++	[31]
3H5	M	DV2	DV2:S	DIII LR	–	+++	–	–	–	[32]
8A1	M	DV3	DV3:S	DIII	–	–	+++	–	–	[33]
DV4 126	H	DV4	DV4:S	DI/DII hinge Q	–	–	–	+++	–	[8]
DV4 131	H	DV4	DV4:S	DI/DII hinge Q	–	–	–	+++	–	[8]
DV4 141	H	DV4	None	DIII	–	–	–	+++	–	[8]
DT000	H	D-CR	DV:S ZIKV:W		+++	+++	+++	++	–	[21]

Dengue specific monoclonal antibodies. A panel of well-defined mouse, human or chimpanzee (M/H/C) derived Mabs were used to characterize sRecE epitopes. Flavivirus cross reactive (F-CR), dengue cross reactive (D-CR), weakly, moderately or strong (W/M/S) neutralizing, E-domain I, II, III (DI, DII, DIII), fusion loop (FL), BC-loop (BC), lateral ridge (LR), quaternary (Q)

ISSN: 1743-422X