Table 5 Gender-stratification analysis on the association between selected SNPs and anti-HEV IgG seropositivity
Gene nomenclature | SNP | Stratum | Anti-HEV IgG | WT/HT/MT | OR(95%CI)/P valuea | ||
|---|---|---|---|---|---|---|---|
Additive | Dominant | Recessive | |||||
APOA4 | rs1268354 | CC/CT/TT | |||||
Male | positive | 187/223/75 | 0.963(0.823–1.126) | 0.893(0.754–1.059) | 0.883(0.708–1.101) | ||
negative | 412/587/163 | P = 0.634 | P = 0.194 | P = 0.268 | |||
Female | positive | 154/190/54 | 0.88(0.692–1.117) | 1.095(0.812–1.476) | 0.833(0.597–1.162) | ||
negative | 366/496/161 | P = 0.293 | P = 0.553 | P = 0.282 | |||
APOE | rs405509 | TT/TG/GG | |||||
Male | positive | 243/209/32 | 0.941(0.796–1.112) | 1.076(0.894–1.294) | 0.998(0.806–1.235) | ||
negative | 581/472/111 | P = 0.473 | P = 0.440 | P = 0.984 | |||
Female | positive | 200/168/30 | 1.089(0.864–1.374) | 0.713(0.472–1.075) | 1.114(0.714–1.737) | ||
negative | 539/414/71 | P = 0.471 | P = 0.106 | P = 0.635 | |||
rs7412 | CC/CT/TT | ||||||
Male | positive | 422/63/1 | 0.707(0.527–0.95) | 1.036(0.775–1.385) | 0.708(0.522–0.96) | ||
negative | 958/210/6 | P = 0.021 | P = 0.811 | P = 0.026 | |||
Female | positive | 335/59/5 | 0.998(0.728–1.367) | 0.351(0.042–2.958) | 1.895(0.597–6.014) | ||
negative | 862/159/7 | P = 0.988 | P = 0.336 | P = 0.278 | |||
rs769450 | AA/AG/GG | ||||||
Male | positive | 297/176/13 | 1.086(0.9–1.311) | 1.004(0.817–1.235) | 1.195(0.959–1.49) | ||
negative | 758/355/52 | P = 0.389 | P = 0.967 | P = 0.112 | |||
Female | positive | 259/124/16 | 0.988(0.775–1.26) | 0.632(0.34–1.177) | 1.116(0.614–2.027) | ||
negative | 668/322/38 | P = 0.924 | P = 0.148 | P = 0.719 | |||