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Fig. 2 | Virology Journal

Fig. 2

From: Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition

Fig. 2

Effect of allosteric NS5B inhibitors on AnxA2-NS5B interaction. Sensorgrams for the injection of a 63 to 1000 nM filibuvir over immobilized NS5B (12,400 RU), and b 63 to 1000 nM filibuvir after an injection of 125 nM AnxA2. The reference cell contained immobilized NS5B (11,765 RU) inactivated by injections of 6 M guanidine-HCl. All sensorgrams are blank injection and reference surface subtracted. Sensorgrams for c interaction between 63 to 1000 nM AnxA2 (bottom curve) and injected simultaneously with 500 nM filibuvir (top curve) over immobilized NS5B (2634 RU), and d interaction between 200 nM NS5B (red) injected simultaneously with 1 mM of filibuvir (green) or dasabuvir (blue) over immobilized AnxA2 (3785 RU)

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