The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population

Table 2 Association of HLA-DP/DQ with HCV susceptibility and clearance

SNPs (genotype)	Group A	Group B	Group C	Group(A + B)/Group C		Group A/Group B
	n (%)	n (%)	n (%)	OR^a	P ^a	OR^b	P ^b
HLA-DP rs9277535
GG	96 (26.1)	64 (33.2)	276 (28.7)	1.00	–	1.00	–
AG	190 (51.6)	83 (43.0)	455 (47.3)	1.02 (0.79–1.33)	0.876	1.60 (1.03–2.48)	0.035
AA	82 (22.3)	46 (23.8)	231 (24.0)	1.00 (0.73–1.37)	0.989	1.35 (0.81–2.27)	0.250
Dominant model				1.01 (0.79–1.30)	0.906	1.52 (1.01–2.28)	0.046
Additive model				1.00 (0.86–1.17)	0.979	1.19 (0.91–1.54)	0.198
HLA-DQ rs7453920
GG	237 (69.3)	119 (66.1)	671 (72.4)	1.00	–	1.00	–
AG	84 (24.6)	55 (30.6)	228 (24.6)	1.26 (0.97–1.65)	0.084	0.90 (0.58–1.39)	0.643
AA	21 (6.1)	6 (3.3)	28 (3.0)	1.84 (1.03–3.29)	0.040	1.96 (0.71–5.37)	0.193
Dominant model				1.33 (1.04–1.71)	0.026	1.00 (0.66–1.52)	0.989
Additive model				1.30 (1.06–1.60)	0.012	1.10 (0.78–1.54)	0.599

Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
Abbreviations: SNPs single nucleotide polymorphisms
Bold type indicates statistically significant results
^aThe P value, odds ratio (OR), 95% confidence intervals (CI) of Group (A + B) versus Group C were calculated on the basis of the logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population
^bThe P value, odds ratio (OR), 95% confidence intervals (CI) of Group A versus Group B were calculated on the basis of the logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes

ISSN: 1743-422X