Skip to main content

Table 2 Association of HLA-DP/DQ with HCV susceptibility and clearance

From: The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population

SNPs (genotype) Group A Group B Group C Group(A + B)/Group C Group A/Group B
  n (%) n (%) n (%) ORa P a ORb P b
HLA-DP rs9277535       
 GG 96 (26.1) 64 (33.2) 276 (28.7) 1.00 1.00
 AG 190 (51.6) 83 (43.0) 455 (47.3) 1.02 (0.79–1.33) 0.876 1.60 (1.03–2.48) 0.035
 AA 82 (22.3) 46 (23.8) 231 (24.0) 1.00 (0.73–1.37) 0.989 1.35 (0.81–2.27) 0.250
Dominant model     1.01 (0.79–1.30) 0.906 1.52 (1.01–2.28) 0.046
Additive model     1.00 (0.86–1.17) 0.979 1.19 (0.91–1.54) 0.198
HLA-DQ rs7453920       
 GG 237 (69.3) 119 (66.1) 671 (72.4) 1.00 1.00
 AG 84 (24.6) 55 (30.6) 228 (24.6) 1.26 (0.97–1.65) 0.084 0.90 (0.58–1.39) 0.643
 AA 21 (6.1) 6 (3.3) 28 (3.0) 1.84 (1.03–3.29) 0.040 1.96 (0.71–5.37) 0.193
Dominant model     1.33 (1.04–1.71) 0.026 1.00 (0.66–1.52) 0.989
Additive model     1.30 (1.06–1.60) 0.012 1.10 (0.78–1.54) 0.599
  1. Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
  2. Abbreviations: SNPs single nucleotide polymorphisms
  3. Bold type indicates statistically significant results
  4. aThe P value, odds ratio (OR), 95% confidence intervals (CI) of Group (A + B) versus Group C were calculated on the basis of the logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population
  5. bThe P value, odds ratio (OR), 95% confidence intervals (CI) of Group A versus Group B were calculated on the basis of the logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes