Prevalence and risk of hepatitis E virus infection in the HIV population of Nepal

Table 1 Characteristics of study subjects and comparison between anti-HEV IgM positive and IgM negative group

Characteristics/ Variables	Total HIV+ subjects (N = 459) N (%) or mean ± SD	Anti-HEV IgM+(N = 70) N (%) or mean ± SD	Anti-HEV IgM–(N = 389) N (%) or mean ± SD	P value^b
Age	36.21 ± 10.35	37.41 ± 11.02	35.99 ± 10.19	0.318
Gender (Male)	274 (59.69)	40 (57.14)	234 (60.15)	0.510^c
Duration of HIV Diagnosis (years)	4.12 ± 2.57	4.57 ± 2.6	4.04 ± 2.56	0.081^d
Living in Kathmandu Valley	198 (43.13)	57 (81.42)	141 (36.24)	<0.001^c,a
CD4+ count (cells/μL)	301.97 ± 117.75	351.73 ± 109.78	293.02 ± 117.03	<0.001^a
ALT	32 ± 12.39	53.9 ± 19.80	28.75 ± 3.79	<0.001^a
AST	35 ± 8.15	42.77 ± 14.85	33.60 ± 5.13	<0.001^a
HBsAg (n)	24 (5.2)	10 (14.28)	14 (3.59)	<0.001^c,a
Anti HCV (n)	342 (74.50)	27 (38.57)	315 (80.97)	<0.001^c,a
Anti-HEV IgG (n)	181 (39.43)	17 (24.28)	164 (42.15)	0.005^{c, a}
HIV Viral load in log cps/ml	2.74 ± 0.46	2.90 ± 0.61	2.71 ± 0.44	0.016^a

Abbreviations: CD4- Cluster of differentiations 4; ALT- Alanine aminotransferase; AST- Aspartate aminotransferase; GGT- Gamma glutamyltranspeptidase; HBsAg- Hepatitis B surface Antigen; HCV- Hepatitis C virus, HEV- Hepatitis E virus, HIV- Human Immunodeficiency virus
^aSignificant
^bSignificance of difference between anti-HEV IgM+ and IgM– group
^cChi squared test
^dMann Whitney U test

ISSN: 1743-422X